Anthracycline antibiotics induce acute renal tubular toxicity in children with cancer

Edit Bárdi, Ildikó Bobok, Anna V. Oláh, J. Kappelmayer, C. Kiss

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Experimental evidence suggests that anthracyclines, widely used in cancer chemotherapy, may impair kidney function. We assessed kidney function by serum creatinine, urinary N-acetyl-β-D-glucosaminidase activity indices (NAGi) and microalbuminuria (MA) in 160 serum and urine samples obtained from 66 children with cancer. The effect of dexrazoxane was analyzed in 6 children on dexrazoxane supportive therapy in conjunction with daunorubicin (DNR) treatment, as compared with 6 children not receiving this agent. NAGi was significantly (pi. DNR resulted in a progressive deterioration of proximal tubular function as determined by linear regression analysis. The mean NAGi in the dexrazoxane-treated group was significantly (p

Original languageEnglish
Pages (from-to)249-253
Number of pages5
JournalPathology and Oncology Research
Volume13
Issue number3
Publication statusPublished - 2007

Fingerprint

Dexrazoxane
Hexosaminidases
Anthracyclines
Daunorubicin
Anti-Bacterial Agents
Kidney
Neoplasms
Serum
Linear Models
Creatinine
Regression Analysis
Urine
Drug Therapy
Therapeutics

Keywords

  • Anthracycline therapy
  • Dexrazoxane
  • Microalbuminuria
  • NAGi
  • Nephrotoxicity

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pathology and Forensic Medicine

Cite this

Anthracycline antibiotics induce acute renal tubular toxicity in children with cancer. / Bárdi, Edit; Bobok, Ildikó; Oláh, Anna V.; Kappelmayer, J.; Kiss, C.

In: Pathology and Oncology Research, Vol. 13, No. 3, 2007, p. 249-253.

Research output: Contribution to journalArticle

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