Antagonism of the effects of calcitonin gene-related peptide and of capsaicin on the guinea-pig isolated ileum by human α-calcitonin gene-related peptide(8-37)

L. Barthó, G. Kóczán, P. Holzer, C. A. Maggi, J. Szolcsányi

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28 Citations (Scopus)

Abstract

The possible mediating role of calcitonin gene-related peptide (CGRP) in the effects of capsaicin in the guinea-pig ileum has been investigated by means of the CGRP antagonist hCGRP(8-37). Submaximal longitudinal muscle relaxation of the histamine-precontracted ileum evoked by rat CGRP (3 nM) or capsaicin (1 μM) was reversed by hCGRP(8-37) (1.5 μM), while that due to adrenaline or neurotensin was not affected. Inhibition of spontaneous circular muscle movements by capsaicin (100 nM) was also reversed by hCGRP(8-37). The CGRP antagonist had no effect on electrical stimulation-evoked ileal contractions or on the longitudinal or circular muscle tone. It is concluded that (a) hCGRP(8-37) is a specific CGRP antagonist in the ileum, apparently devoid of intrinsic activity or any effect not related to CGRP; (b) the inhibitory actions of capsaicin on the longitudinal and circular muscles of the ileum are mediated, at least in part, by CGRP.

Original languageEnglish
Pages (from-to)156-159
Number of pages4
JournalNeuroscience Letters
Volume129
Issue number1
DOIs
Publication statusPublished - Aug 5 1991

Keywords

  • CGRP antagonist
  • Calcitonin gene-related peptide
  • Capsaicin
  • Enteric

ASJC Scopus subject areas

  • Neuroscience(all)

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