Antagonism between adenosine and bromobenzoyl-methyladamantylamine, A K+ channel blocker, in atrial myocardium of guinea pig

János Mészáros, Karoly Kelemen, Valéria Kecskeméti, József Szegi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The effect of bromobenzoyl-methyladamantylamine (BMA) on the adenosine-induced changes in the electrical and mechanical activity of the atrial muscle, and the effect of adenosine on the slow action potentials induced by BMA in K+-depolarized atrial myocardium of guinea pig were studied. BMA was able to antagonize the adenosine-induced shortening of the action potential duration and negative inotropic effect. This action of BMA was potentiated by theophylline, and reduced by dipyridamole. Adenosine depressed the BMA-induced slow action potentials. The results suggest that there may be an antagonism between BMA and adenosine.

Original languageEnglish
Pages (from-to)265-268
Number of pages4
JournalEuropean Journal of Pharmacology
Volume98
Issue number2
DOIs
Publication statusPublished - Feb 17 1984

Keywords

  • Action potential
  • Adamante
  • Adenosine
  • Guinea pig heart
  • Slow responses

ASJC Scopus subject areas

  • Pharmacology

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