Animal models of preeclampsia

Eduardo Podjarny, G. Losonczy, Chris Baylis

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

There have been many attempts to produce animal models that mimic the hypertensive disorders of pregnancy, especially preeclampsia, but most are incomplete when compared to the full spectrum of the human disease. This review assesses a number of these models, organized according to the investigators attempt to focus on a specific pathogenic mechanism believed to play a role in the human disease. These mechanisms include uterine ischemia, impairments in the nitric oxide system, insulin resistance, overactivity of the autonomic nervous and/or renin-angiotensin systems, activation of a systemic inflammatory response, and most recently, activation of circulating proteins that interfere with angiogenesis. In addition a model of renal disease that mimics superimposed preeclampsia is discussed. Defining these animal models should help in our quest to understand the cause, as well as to test preventative and therapeutic strategies in the management of these hypertensive disorders of pregnancy.

Original languageEnglish
Pages (from-to)596-606
Number of pages11
JournalSeminars in Nephrology
Volume24
Issue number6 SPEC.ISS.
DOIs
Publication statusPublished - Nov 2004

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Pre-Eclampsia
Animal Models
Pregnancy
Renin-Angiotensin System
Insulin Resistance
Nitric Oxide
Ischemia
Research Personnel
Kidney
Proteins
Therapeutics

Keywords

  • glomerular endotheliosis
  • hypertension
  • intrauterine growth retardation
  • proteinuria

ASJC Scopus subject areas

  • Nephrology

Cite this

Animal models of preeclampsia. / Podjarny, Eduardo; Losonczy, G.; Baylis, Chris.

In: Seminars in Nephrology, Vol. 24, No. 6 SPEC.ISS., 11.2004, p. 596-606.

Research output: Contribution to journalArticle

Podjarny, E, Losonczy, G & Baylis, C 2004, 'Animal models of preeclampsia', Seminars in Nephrology, vol. 24, no. 6 SPEC.ISS., pp. 596-606. https://doi.org/10.1016/j.semnephrol.2004.07.011
Podjarny, Eduardo ; Losonczy, G. ; Baylis, Chris. / Animal models of preeclampsia. In: Seminars in Nephrology. 2004 ; Vol. 24, No. 6 SPEC.ISS. pp. 596-606.
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