Animal models of major depression and their clinical implications

Boldizsár Czéh, Eberhard Fuchs, Ove Wiborg, M. Simón

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

Major depressive disorder is a common, complex, and potentially life-threatening mental disorder that imposes a severe social and economic burden worldwide. Over the years, numerous animal models have been established to elucidate pathophysiology that underlies depression and to test novel antidepressant treatment strategies. Despite these substantial efforts, the animal models available currently are of limited utility for these purposes, probably because none of the models mimics this complex disorder fully. It is presumable that psychiatric illnesses, such as affective disorders, are related to the complexity of the human brain. Here, we summarize the animal models that are used most commonly for depression, and discuss their advantages and limitations. We discuss genetic models, including the recently developed optogenetic tools and the stress models, such as the social stress, chronic mild stress, learned helplessness, and early-life stress paradigms. Moreover, we summarize briefly the olfactory bulbectomy model, as well as models that are based on pharmacological manipulations and disruption of the circadian rhythm. Finally, we highlight common misinterpretations and often-neglected important issues in this field.

Original languageEnglish
Pages (from-to)293-310
Number of pages18
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume64
DOIs
Publication statusPublished - Jan 4 2016

Fingerprint

Animal Models
Depression
Optogenetics
Learned Helplessness
Genetic Models
Major Depressive Disorder
Circadian Rhythm
Mood Disorders
Psychological Stress
Mental Disorders
Antidepressive Agents
Psychiatry
Economics
Pharmacology
Brain
Therapeutics

Keywords

  • Animal model
  • Chronic stress
  • CMS
  • Depression
  • Mood disorder

ASJC Scopus subject areas

  • Biological Psychiatry
  • Pharmacology

Cite this

Animal models of major depression and their clinical implications. / Czéh, Boldizsár; Fuchs, Eberhard; Wiborg, Ove; Simón, M.

In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 64, 04.01.2016, p. 293-310.

Research output: Contribution to journalArticle

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