Animal models of fetal renal disease

Peter M. Cuckow, P. Nyírády, Paul J D Winyard

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Fetal models of urinary tract disease have been used for many years and have provided unique and important insights into the pathophysiology of these conditions. This review will summarize the principal model systems used and the current directions of investigation. These models (including rabbit, opossum, sheep and recently swine) have demonstrated that in utero obstruction of the urinary tract alters renal growth, differentiation and produces stereotypical patterns of tissue response, particularly fibrosis. New molecular understanding of these processes has identified specific mechanisms that may be key elements in the development of renal dysfunction due to obstruction. These factors include the renin-angiotensin system (RAS) and its interaction with tgf-β in altering growth regulation and tissue fibrosis. These factors offer the prospect of clinical utility as markers of disease progression as well as pharmacologic therapy. Gene knockout systems have opened a new horizon of molecular models of congenital obstructive uropathy with insights into the role of the RAS in particular. It remains to be defined how closely these knockouts represent the human conditions they resemble. Continued application of fetal models of urinary obstruction, integrating large animal and knockout systems offers promise for improved diagnosis and treatment in these challenging conditions.

Original languageEnglish
Pages (from-to)917-923
Number of pages7
JournalPrenatal Diagnosis
Volume21
Issue number11
DOIs
Publication statusPublished - 2001

Fingerprint

Fetal Diseases
Renin-Angiotensin System
Fibrosis
Animal Models
Kidney
Urologic Diseases
Opossums
Gene Knockout Techniques
Molecular Models
Growth
Urinary Tract
Disease Progression
Sheep
Swine
Rabbits
Therapeutics
Direction compound

Keywords

  • Animal models
  • Bladder
  • Fetus
  • Hydronephrosis
  • Kidney
  • Urinary obstruction

ASJC Scopus subject areas

  • Genetics(clinical)
  • Obstetrics and Gynaecology

Cite this

Animal models of fetal renal disease. / Cuckow, Peter M.; Nyírády, P.; Winyard, Paul J D.

In: Prenatal Diagnosis, Vol. 21, No. 11, 2001, p. 917-923.

Research output: Contribution to journalArticle

Cuckow, PM, Nyírády, P & Winyard, PJD 2001, 'Animal models of fetal renal disease', Prenatal Diagnosis, vol. 21, no. 11, pp. 917-923. https://doi.org/10.1002/pd.211
Cuckow, Peter M. ; Nyírády, P. ; Winyard, Paul J D. / Animal models of fetal renal disease. In: Prenatal Diagnosis. 2001 ; Vol. 21, No. 11. pp. 917-923.
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