It could be established by means of the Allen Doisy test, mouse uterine growth test and by investigations on infantile female mice that epimestrol is a substance of weak oestrogen effect. The intensity of its oestrogen effect is approximately half of that of oestriols. The oestrus cycle of the sexually mature female mice is influenced by it depending on the dose. In case rats, as a result of epimestrol loading, there follows an immediate gonadotrophin release and, in connection with that, an increased secretion of it. The effect of a single epimestrol administration is lasting for about 72 hr. There are considerable differences in the effect depending upon the dose.
|Translated title of the contribution||Animal experimental studies on the pharmacology of epimestrol|
|Number of pages||8|
|Publication status||Published - Jan 1 1973|
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