Animal cloning by nuclear transfer

State-of-the-art and future perspectives

A. Dinnyés, Agnes Szmolenszky

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Model organisms are essential to study the genetic basis of human diseases. Transgenic mammalian models, especially genetic knock-out mice have catalysed the progress in this area. To continue the advancement, further sophisticated and refined models are crucially needed to study the genetic basis and manifestations of numerous human diseases. Coinciding with the start of the new era of post-genomic research, new tools for establishment of transgenesis, such as nuclear transfer and gene targeting in somatic cells, have become available, offering a unique opportunity for the generation of transgenic animal models. The new technology provides important tools for comparative functional genomics to promote the interpretation and increase the practical value of the data generated in numerous mouse models. This paper discusses the state-of-the-art of the nuclear replacement technology and presents future perspectives.

Original languageEnglish
Pages (from-to)585-588
Number of pages4
JournalActa Biochimica Polonica
Volume52
Issue number3
Publication statusPublished - 2005

Fingerprint

Cloning
Organism Cloning
Animals
Technology
Gene Transfer Techniques
Genetically Modified Animals
Gene Targeting
Genetic Models
Medical Genetics
Genomics
Knockout Mice
Animal Models
Research
Genes

Keywords

  • Animal models
  • Cloning
  • Epigenetics
  • Transgenic

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry

Cite this

Animal cloning by nuclear transfer : State-of-the-art and future perspectives. / Dinnyés, A.; Szmolenszky, Agnes.

In: Acta Biochimica Polonica, Vol. 52, No. 3, 2005, p. 585-588.

Research output: Contribution to journalArticle

@article{eb3d6e125ea54a78b9ceb02a7f19115f,
title = "Animal cloning by nuclear transfer: State-of-the-art and future perspectives",
abstract = "Model organisms are essential to study the genetic basis of human diseases. Transgenic mammalian models, especially genetic knock-out mice have catalysed the progress in this area. To continue the advancement, further sophisticated and refined models are crucially needed to study the genetic basis and manifestations of numerous human diseases. Coinciding with the start of the new era of post-genomic research, new tools for establishment of transgenesis, such as nuclear transfer and gene targeting in somatic cells, have become available, offering a unique opportunity for the generation of transgenic animal models. The new technology provides important tools for comparative functional genomics to promote the interpretation and increase the practical value of the data generated in numerous mouse models. This paper discusses the state-of-the-art of the nuclear replacement technology and presents future perspectives.",
keywords = "Animal models, Cloning, Epigenetics, Transgenic",
author = "A. Dinny{\'e}s and Agnes Szmolenszky",
year = "2005",
language = "English",
volume = "52",
pages = "585--588",
journal = "Acta Biochimica Polonica",
issn = "0001-527X",
publisher = "Acta Biochimica Polonica",
number = "3",

}

TY - JOUR

T1 - Animal cloning by nuclear transfer

T2 - State-of-the-art and future perspectives

AU - Dinnyés, A.

AU - Szmolenszky, Agnes

PY - 2005

Y1 - 2005

N2 - Model organisms are essential to study the genetic basis of human diseases. Transgenic mammalian models, especially genetic knock-out mice have catalysed the progress in this area. To continue the advancement, further sophisticated and refined models are crucially needed to study the genetic basis and manifestations of numerous human diseases. Coinciding with the start of the new era of post-genomic research, new tools for establishment of transgenesis, such as nuclear transfer and gene targeting in somatic cells, have become available, offering a unique opportunity for the generation of transgenic animal models. The new technology provides important tools for comparative functional genomics to promote the interpretation and increase the practical value of the data generated in numerous mouse models. This paper discusses the state-of-the-art of the nuclear replacement technology and presents future perspectives.

AB - Model organisms are essential to study the genetic basis of human diseases. Transgenic mammalian models, especially genetic knock-out mice have catalysed the progress in this area. To continue the advancement, further sophisticated and refined models are crucially needed to study the genetic basis and manifestations of numerous human diseases. Coinciding with the start of the new era of post-genomic research, new tools for establishment of transgenesis, such as nuclear transfer and gene targeting in somatic cells, have become available, offering a unique opportunity for the generation of transgenic animal models. The new technology provides important tools for comparative functional genomics to promote the interpretation and increase the practical value of the data generated in numerous mouse models. This paper discusses the state-of-the-art of the nuclear replacement technology and presents future perspectives.

KW - Animal models

KW - Cloning

KW - Epigenetics

KW - Transgenic

UR - http://www.scopus.com/inward/record.url?scp=27644491383&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=27644491383&partnerID=8YFLogxK

M3 - Article

VL - 52

SP - 585

EP - 588

JO - Acta Biochimica Polonica

JF - Acta Biochimica Polonica

SN - 0001-527X

IS - 3

ER -