Data of our 254 patients who were treated with rt-PA between 1st of Jan, 2011 and 31∗ of Dec, 2014 were processed. We focused on angioneurotic oedema as allergic complication of thrombolysis which caused life threatening respiratory obstruction in two cases. We describe these two patients' history. Out of 254 patients six (2.3%) suffered angioneurotic edema caused respiratory obstruction in two (0.90%) cases. This occurrence is approximately 1.3-5.1% in literature. Five, out of six patients who suffered from angioneurotic oedei ma, had been treated with ACE inhibitors or ARB before. The role of ACE inhibitors is known in metabolism of brady- kinin cascade. Plasmin which present during thrombolysis, precipitates biochemical mechanisms of this potential life threatening complication. Therefore rt-PA alone can be the cause of angioedema, but it can be more frequent together with ACE inhibitors therapy.
ASJC Scopus subject areas
- Clinical Neurology