Angiogenesis in Rheumatoid Arthritis: Pathogenic and Clinical Significance

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Abstract

In summary, angiogenesis, the formation of new blood vessels, is important in leukocyte extravasation and thus the pathogenesis of RA. The outcome of neovascularization highly depends on the imbalance between angiogenic and angiostatic mediators produced in the rheumatoid synovium. Therefore, angiogenesis research is important for the understanding of the pathogenesis of inflammatory arthritis. In addition, existing and potential angiostatic drugs may be useful for future therapy of RA.

Original languageEnglish
Pages (from-to)27-41
Number of pages15
JournalJournal of Investigative Medicine
Volume46
Issue number2
Publication statusPublished - Feb 1998

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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