Angiogenesis in inflammation

Z. Szekanecz, L. Módis, A. E. Koch

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)


Angiogenesis is the formation of new capillaries from preexisting vessels. A number of soluble and cell-bound factors may stimulate neovascularization. The perpetuation of angiogenesis involving numerous soluble and cell surface-bound mediators has been associated with neovascular eye diseases, as well as rheumatoid arthritis. These angiogenic mediators, among others, include growth factors, primarily vascular endothelial growth factor (VEGF) and hypoxia-inducible factors (HIFs), as well as pro-inflammatory cytokines, various chemokines, matrix components, cell adhesion molecules, proteases, and others. Among the several potential angiogenesis inhibitors, targeting of VEGF, HIF-1, angiogenic chemokines, tumor necrosis factor-α, and the αVβ3 integrin may attenuate the action of angiogenic mediators and thus neovascularization. In addition, some naturally produced or synthetic compounds, including angiostatin, endostatin, paclitaxel, fumagillin analogs, 2-methoxyestradiol, and thalidomide, may be included in the management of neovascular diseases.

Original languageEnglish
Title of host publicationEncyclopedia of the Eye
Number of pages5
ISBN (Electronic)9780123742032
ISBN (Print)9780123741981
Publication statusPublished - Jan 1 2010



  • Angiogenesis
  • Inflammation
  • Ocular neovascularization
  • Rheumatoid arthritis
  • VEGF

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Szekanecz, Z., Módis, L., & Koch, A. E. (2010). Angiogenesis in inflammation. In Encyclopedia of the Eye (pp. 83-87). Elsevier.