Angiogenesis is the formation of new capillaries from preexisting vessels. A number of soluble and cell-bound factors may stimulate neovascularization. The perpetuation of angiogenesis involving numerous soluble and cell surface-bound mediators has been associated with neovascular eye diseases, as well as rheumatoid arthritis. These angiogenic mediators, among others, include growth factors, primarily vascular endothelial growth factor (VEGF) and hypoxia-inducible factors (HIFs), as well as pro-inflammatory cytokines, various chemokines, matrix components, cell adhesion molecules, proteases, and others. Among the several potential angiogenesis inhibitors, targeting of VEGF, HIF-1, angiogenic chemokines, tumor necrosis factor-α, and the αVβ3 integrin may attenuate the action of angiogenic mediators and thus neovascularization. In addition, some naturally produced or synthetic compounds, including angiostatin, endostatin, paclitaxel, fumagillin analogs, 2-methoxyestradiol, and thalidomide, may be included in the management of neovascular diseases.
|Title of host publication||Encyclopedia of the Eye|
|Number of pages||5|
|Publication status||Published - Jan 1 2010|
- Ocular neovascularization
- Rheumatoid arthritis
ASJC Scopus subject areas