Angiogenesis-dependent diseases and angiogenesis therapy

József Tímár, Balázs Döme, Károly Fazekas, Ágnes Janovics, Sándor Paku

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

The discovery of the molecular mechanisms of physiological vasculogenesis and pathological angiogenesis helped to recognize two classes of diseases: one where the therapeutic angiogenesis can repair the tissue damages (arteriosclerosis, myocardial infarction, limb ischemia) and the other one where inhibition of pathological angiogenesis can cure the disease or delay its progression (retinopathies, benign and malignant angiogenic tumors, progression of malignant tumors). Although there are an exponentially growing number of new synthetic molecules characterized mainly by antiangiogenic properties, the discovery of a large battery of natural pro- and anti-angiogenic factors suggests that this may provide a more physiological approach to treat both class of angiogenesis-dependent diseases in the near future.

Original languageEnglish
Pages (from-to)85-94
Number of pages10
JournalPathology and Oncology Research
Volume7
Issue number2
DOIs
Publication statusPublished - Jan 1 2001

Keywords

  • Angiogenesis
  • Anti-angiogenesis
  • Diseases
  • Pro-angiogenesis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oncology
  • Cancer Research

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