Angiogenesis and vasculogenesis in rheumatoid arthritis

Z. Szekanecz, Timea Besenyei, Ágnes Szentpétery, Alisa E. Koch

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

PURPOSE OF REVIEW: Angiogenesis is the formation of new capillaries from pre-existing vessels, whereas vasculogenesis is de-novo capillary formation from endothelial precursor cells (EPCs). Current understanding of the role of angiogenesis and vasculogenesis in rheumatoid arthritis (RA) and possibilities of therapeutic intervention should be summarized. RECENT FINDINGS: There have been many recent studies on the role of the hypoxia and hypoxia-inducible factor (HIF)-vascular endothelial growth factor (VEGF)-angiopoietin axis in angiogenesis associated with RA. The role of additional growth factors, chemokines, cytokines, matrix components and adhesion molecules has been further characterized. Macrophage migration inhibitory factor (MIF) may link inflammation, angiogenesis and atherosclerosis. Junctional adhesion molecules (JAMs) and focal adhesion kinases (FAKs) have recently been implicated in inflammatory angiogenesis. Novel information regarding the role of serum amyloid A (SAA) and sphingosine kinase has become available. Most of these angiogenic factors have recently been targeted using various techniques and arthritis models. Whereas angiogenesis is abundant in RA, there is defective EPC function and vasculogenesis leading to atherosclerosis and vascular disease in arthritis. Treatment with EPCs already under investigation in vascular diseases may also be attempted in RA. SUMMARY: Targeting angiogenesis and restoration of vasculogenesis may be beneficial for the therapy and outcome of RA.

Original languageEnglish
Pages (from-to)299-306
Number of pages8
JournalCurrent Opinion in Rheumatology
Volume22
Issue number3
DOIs
Publication statusPublished - May 2010

Fingerprint

Rheumatoid Arthritis
Endothelial Cells
Vascular Diseases
Arthritis
Atherosclerosis
Junctional Adhesion Molecules
Angiopoietins
Macrophage Migration-Inhibitory Factors
Serum Amyloid A Protein
Focal Adhesion Protein-Tyrosine Kinases
Angiogenesis Inducing Agents
Chemokines
Vascular Endothelial Growth Factor A
Intercellular Signaling Peptides and Proteins
Cytokines
Inflammation
Therapeutics
Hypoxia

Keywords

  • Angiogenesis
  • Angiostasis
  • Rheumatoid arthritis
  • Therapy
  • Vasculogenesis

ASJC Scopus subject areas

  • Rheumatology

Cite this

Angiogenesis and vasculogenesis in rheumatoid arthritis. / Szekanecz, Z.; Besenyei, Timea; Szentpétery, Ágnes; Koch, Alisa E.

In: Current Opinion in Rheumatology, Vol. 22, No. 3, 05.2010, p. 299-306.

Research output: Contribution to journalArticle

Szekanecz, Z. ; Besenyei, Timea ; Szentpétery, Ágnes ; Koch, Alisa E. / Angiogenesis and vasculogenesis in rheumatoid arthritis. In: Current Opinion in Rheumatology. 2010 ; Vol. 22, No. 3. pp. 299-306.
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