Angiogenesis and chemokines in rheumatoid arthritis and other systemic inflammatory rheumatic diseases

Edit Bodolay, Alisa E. Koch, Joon Kim, Gyula Szegedi, Zoltan Szekanecz

Research output: Contribution to journalReview article

98 Citations (Scopus)


Angiogenesis, the formation of new vessels, is important in the pathogenesis of rheumatoid arthritis (RA) and other inflammatory diseases. Chemotactic cytokines termed chemokines mediate the ingress of leukocytes, including neutrophils and monocytes into the inflamed synovium. In this review, authors discuss the role of the most important angiogenic factors and angiogenesis inhibitors, as well as relevant chemokines and chemokine receptors involved in chronic inflammatory rheumatic diseases. RA was chosen as a prototype to discuss these issues, as the majority of studies on the role of angiogenesis and chemokines in inflammatory diseases were carried out in arthritis. However, other systemic inflammatory (autoimmune) diseases including systemic lupus erythematosus (SLE), systemic sclerosis (SSc), Sjögren's syndrome (SS), mixed connective tissue disease (MCTD), polymyositis/ dermatomyositis (PM/DM) and systemic vasculites are also discussed in this context. As a number of chemokines may also play a role in neovascularizaton, this issue is also described here. Apart from discussing the pathogenic role of angiogenesis and chemokines, authors also review the regulation of angiogenesis and chemokine production by other inflammatory meditors, as well as the important relevance of neovascularization and chemokines for antirheumatic intervention.

Original languageEnglish
Pages (from-to)357-376
Number of pages20
JournalJournal of Cellular and Molecular Medicine
Issue number3
Publication statusPublished - 2002


  • Angiogenesis
  • Chemokine
  • Chemokine receptor
  • Dermatomyositis
  • Mixed connective tissue disease
  • Polymyositis
  • Rheumatoid arthritis
  • Sjögren's syndrome
  • Systemic lupus erythematosus
  • Systemic sclerosis
  • Vasculitis

ASJC Scopus subject areas

  • Molecular Medicine
  • Cell Biology

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