Angioedema due to acquired Cl-esterase inhibitor deficiency in a patient with Helicobacter pylori infection

Henriette Farkas, L. Gyeney, P. Majthényi, G. Füst, L. Varga

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The first component of the classical pathway of the complement system, Cl is regulated by a serum protein, the Cl-esterase inhibitor (Cl-INH). Deficiency of this protein leads to the release of vasoactive mediators (C2 kinin and bradykinin) that increase vascular permeability and can induce edema formation in subcutaneous and submucosal tissues. The genetic variant of Cl-INH deficiency is inherited as an autosomal dominant trait and causes hereditary angioneurotic edema. The acquired form of Cl-INH deficiency is characterized by similar manifestations and can occur in association with lymphoproliferative diseases, malignancy, immune disorders, and infections. The authors present a case of acquired Cl-INH deficiency in a patient with Helicobacter pylori infection. Complete eradication of this pathogen was followed by the resolution of symptoms and normalization of serum complement levels. It seems therefore probable that in this patient, acquired Cl-INH deficiency was related to Helicobacter pylori infection. To our best knowledge, no similar observations have been published so far. Specific immune reactions are important contributing factors in H. pylori. Excessive consumption of complement by antibodies directed against H. pylori is a potential cause of Cl-INH deficiency observed in our case.

Original languageEnglish
Pages (from-to)513-518
Number of pages6
JournalZeitschrift fur Gastroenterologie
Volume37
Issue number6
Publication statusPublished - Jun 1999

Fingerprint

Angioedema
Helicobacter Infections
Esterases
Helicobacter pylori
Hereditary Angioedemas
Classical Complement Pathway
Protein Deficiency
Kinins
Immune System Diseases
Subcutaneous Tissue
Capillary Permeability
Bradykinin
Blood Proteins
Edema
Antibodies
Infection
Serum
Neoplasms

Keywords

  • Angioedema
  • Cl-esterase inhibitor
  • Complement
  • Helicobacter pylori

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Angioedema due to acquired Cl-esterase inhibitor deficiency in a patient with Helicobacter pylori infection. / Farkas, Henriette; Gyeney, L.; Majthényi, P.; Füst, G.; Varga, L.

In: Zeitschrift fur Gastroenterologie, Vol. 37, No. 6, 06.1999, p. 513-518.

Research output: Contribution to journalArticle

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