ANF-like peptide(s) in the peripheral autonomic nervous system

Waldemar Debinski, Jolanta Gutkowska, Otto Kuchel, Karoly Racz, Nguyen T. Buu, Marc Cantin, Jacques Genest

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The recent demonstration of the atrial natriuretic factor (ANF) within the brain has been extended in the present study by the additional localization of ANF-like activity in the peripheral nervous structures. Using a sensitive radioimmunoassay, it was possible to detect ANF-like immunoreactive peptide(s) in crude and chromatographically separated extracts of parasympathetic rat ganglia. The partially purified ANF-like peptide exhibited a biological action similar to cardiac ANF. This finding supports a possible involvement of ANF in the regulation of both, central and peripheral neuronal activities.

Original languageEnglish
Pages (from-to)279-284
Number of pages6
JournalBiochemical and biophysical research communications
Issue number1
Publication statusPublished - Jan 14 1986


ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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