ANF-like peptide(s) in the peripheral autonomic nervous system

Waldemar Debinski, Jolanta Gutkowska, Otto Kuchel, Karoly Racz, Nguyen T. Buu, Marc Cantin, Jacques Genest

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

The recent demonstration of the atrial natriuretic factor (ANF) within the brain has been extended in the present study by the additional localization of ANF-like activity in the peripheral nervous structures. Using a sensitive radioimmunoassay, it was possible to detect ANF-like immunoreactive peptide(s) in crude and chromatographically separated extracts of parasympathetic rat ganglia. The partially purified ANF-like peptide exhibited a biological action similar to cardiac ANF. This finding supports a possible involvement of ANF in the regulation of both, central and peripheral neuronal activities.

Original languageEnglish
Pages (from-to)279-284
Number of pages6
JournalBiochemical and biophysical research communications
Volume134
Issue number1
DOIs
Publication statusPublished - Jan 14 1986

    Fingerprint

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this