Aneurysmal bone cyst

Its pathogenesis based on angiographic, immunohistochemical and electron microscopic studies

M. Szendrői, Gabriella Arató, Ali Ezzati, Kálmán Hüttl, Péter Szavcsur

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Based on angiographic, immunohistochemical as well as electron microscopic findings, authors outline a hypothesis for the etiopathogenesis of aneurysmal bone cysts. No changes were found at the arterial site in 16 studied aneurysmal bone cysts, with no signs of an arteriovenous shunt. In certain cases, however, dilated and tortous efferent veins became visible in the late venous phase. Due to the impedance of venous flow, the intracystic pressure increases and the small veins become dilated causing formation of aneurysmal slits. This is supported by the immunohistochemical finding that S-actin shows concentric arrangement around the aneurysmal cavities. Endothelial lining and basal membrane remnants were detectable in places, though the aneurysmal slits were devoid of continuous endothelial lining and basal membrane. We suggested that the aneurysmal bone cyst corresponds to a hemodynamic disturbance and is due to primary or secondary venous malformation of the bones.

Original languageEnglish
Pages (from-to)277-281
Number of pages5
JournalPathology and Oncology Research
Volume4
Issue number4
Publication statusPublished - 1998

Fingerprint

Aneurysmal Bone Cysts
Electrons
Veins
Membranes
Electric Impedance
Actins
Hemodynamics
Pressure
Bone and Bones

Keywords

  • Aneurysmal bone cyst
  • Angiography
  • Histology
  • Pathogenesis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pathology and Forensic Medicine

Cite this

Aneurysmal bone cyst : Its pathogenesis based on angiographic, immunohistochemical and electron microscopic studies. / Szendrői, M.; Arató, Gabriella; Ezzati, Ali; Hüttl, Kálmán; Szavcsur, Péter.

In: Pathology and Oncology Research, Vol. 4, No. 4, 1998, p. 277-281.

Research output: Contribution to journalArticle

Szendrői, M. ; Arató, Gabriella ; Ezzati, Ali ; Hüttl, Kálmán ; Szavcsur, Péter. / Aneurysmal bone cyst : Its pathogenesis based on angiographic, immunohistochemical and electron microscopic studies. In: Pathology and Oncology Research. 1998 ; Vol. 4, No. 4. pp. 277-281.
@article{a641a7d976734ce1862d2ef47b803b7b,
title = "Aneurysmal bone cyst: Its pathogenesis based on angiographic, immunohistochemical and electron microscopic studies",
abstract = "Based on angiographic, immunohistochemical as well as electron microscopic findings, authors outline a hypothesis for the etiopathogenesis of aneurysmal bone cysts. No changes were found at the arterial site in 16 studied aneurysmal bone cysts, with no signs of an arteriovenous shunt. In certain cases, however, dilated and tortous efferent veins became visible in the late venous phase. Due to the impedance of venous flow, the intracystic pressure increases and the small veins become dilated causing formation of aneurysmal slits. This is supported by the immunohistochemical finding that S-actin shows concentric arrangement around the aneurysmal cavities. Endothelial lining and basal membrane remnants were detectable in places, though the aneurysmal slits were devoid of continuous endothelial lining and basal membrane. We suggested that the aneurysmal bone cyst corresponds to a hemodynamic disturbance and is due to primary or secondary venous malformation of the bones.",
keywords = "Aneurysmal bone cyst, Angiography, Histology, Pathogenesis",
author = "M. Szendrői and Gabriella Arat{\'o} and Ali Ezzati and K{\'a}lm{\'a}n H{\"u}ttl and P{\'e}ter Szavcsur",
year = "1998",
language = "English",
volume = "4",
pages = "277--281",
journal = "Pathology and Oncology Research",
issn = "1219-4956",
publisher = "Springer Netherlands",
number = "4",

}

TY - JOUR

T1 - Aneurysmal bone cyst

T2 - Its pathogenesis based on angiographic, immunohistochemical and electron microscopic studies

AU - Szendrői, M.

AU - Arató, Gabriella

AU - Ezzati, Ali

AU - Hüttl, Kálmán

AU - Szavcsur, Péter

PY - 1998

Y1 - 1998

N2 - Based on angiographic, immunohistochemical as well as electron microscopic findings, authors outline a hypothesis for the etiopathogenesis of aneurysmal bone cysts. No changes were found at the arterial site in 16 studied aneurysmal bone cysts, with no signs of an arteriovenous shunt. In certain cases, however, dilated and tortous efferent veins became visible in the late venous phase. Due to the impedance of venous flow, the intracystic pressure increases and the small veins become dilated causing formation of aneurysmal slits. This is supported by the immunohistochemical finding that S-actin shows concentric arrangement around the aneurysmal cavities. Endothelial lining and basal membrane remnants were detectable in places, though the aneurysmal slits were devoid of continuous endothelial lining and basal membrane. We suggested that the aneurysmal bone cyst corresponds to a hemodynamic disturbance and is due to primary or secondary venous malformation of the bones.

AB - Based on angiographic, immunohistochemical as well as electron microscopic findings, authors outline a hypothesis for the etiopathogenesis of aneurysmal bone cysts. No changes were found at the arterial site in 16 studied aneurysmal bone cysts, with no signs of an arteriovenous shunt. In certain cases, however, dilated and tortous efferent veins became visible in the late venous phase. Due to the impedance of venous flow, the intracystic pressure increases and the small veins become dilated causing formation of aneurysmal slits. This is supported by the immunohistochemical finding that S-actin shows concentric arrangement around the aneurysmal cavities. Endothelial lining and basal membrane remnants were detectable in places, though the aneurysmal slits were devoid of continuous endothelial lining and basal membrane. We suggested that the aneurysmal bone cyst corresponds to a hemodynamic disturbance and is due to primary or secondary venous malformation of the bones.

KW - Aneurysmal bone cyst

KW - Angiography

KW - Histology

KW - Pathogenesis

UR - http://www.scopus.com/inward/record.url?scp=0032455013&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032455013&partnerID=8YFLogxK

M3 - Article

VL - 4

SP - 277

EP - 281

JO - Pathology and Oncology Research

JF - Pathology and Oncology Research

SN - 1219-4956

IS - 4

ER -