Aneurysmal bone cyst: Its pathogenesis based on angiographic, immunohistochemical and electron microscopic studies

Miklós Szendroi, Gabriella Arató, Ali Ezzati, Kálmán Hüttl, Péter Szavcsur

Research output: Contribution to journalArticle

23 Citations (Scopus)


Based on angiographic, immunohistochemical as well as electron microscopic findings, authors outline a hypothesis for the etiopathogenesis of aneurysmal bone cysts. No changes were found at the arterial site in 16 studied aneurysmal bone cysts, with no signs of an arteriovenous shunt. In certain cases, however, dilated and tortous efferent veins became visible in the late venous phase. Due to the impedance of venous flow, the intracystic pressure increases and the small veins become dilated causing formation of aneurysmal slits. This is supported by the immunohistochemical finding that S-actin shows concentric arrangement around the aneurysmal cavities. Endothelial lining and basal membrane remnants were detectable in places, though the aneurysmal slits were devoid of continuous endothelial lining and basal membrane. We suggested that the aneurysmal bone cyst corresponds to a hemodynamic disturbance and is due to primary or secondary venous malformation of the bones.

Original languageEnglish
Pages (from-to)277-281
Number of pages5
JournalPathology and Oncology Research
Issue number4
Publication statusPublished - Jan 1 1998



  • Aneurysmal bone cyst
  • Angiography
  • Histology
  • Pathogenesis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oncology
  • Cancer Research

Cite this