Anatomical distribution of nucleoside system in the human brain and implications for therapy

Research output: Chapter in Book/Report/Conference proceedingChapter

12 Citations (Scopus)

Abstract

Nucleosides have a wide range of physiological and pathophysiological roles in the human brain as modulators of a variety of neural functions. For example, adenosine, inosine, guanosine, and uridine participate in the mechanisms underlying memory, cognition, sleep, pain, depression, schizophrenia, epilepsy, Alzheimer's disease, Huntington's disease, and Parkinson's disease. Consequently, increasing attention is now being given to the specific role of nucleosides in physiological and pathological processes in the human brain. Different elements of nucleoside system, including nucleoside concentrations, metabolic enzyme activity, and expression of nucleoside transporters and receptors, may be changed under normal and pathological conditions. The alterations suggest that interlinked elements of the nucleoside system are functioning in a tightly concerted manner. Nucleoside levels, activity of nucleoside metabolic enzymes, and expression of nucleoside transporters and receptors are unevenly distributed in the brain, suggesting that nucleosides have different roles in functionally distinct human brain areas. The aim of this chapter is to summarize our present knowledge of the anatomical distribution of nucleoside system in the human brain, placing emphasis on potential therapeutic pharmacological strategies.

Original languageEnglish
Title of host publicationAdenosine: A Key Link between Metabolism and Brain Activity
PublisherSpringer New York
Pages621-656
Number of pages36
ISBN (Print)9781461439035, 1461439027, 9781461439028
DOIs
Publication statusPublished - Nov 1 2013

Fingerprint

Nucleosides
Brain
Nucleoside Transport Proteins
Therapeutics
Physiological Phenomena
Inosine
Guanosine
Uridine
Huntington Disease
Pathologic Processes
Enzymes
Adenosine
Cognition
Parkinson Disease
Epilepsy
Schizophrenia
Alzheimer Disease
Sleep
Pharmacology
Depression

Keywords

  • Anatomical distribution of nucleoside system
  • Human brain diseases and therapy
  • Nucleosides

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

Cite this

Kovács, Z., & Dobolyi, A. (2013). Anatomical distribution of nucleoside system in the human brain and implications for therapy. In Adenosine: A Key Link between Metabolism and Brain Activity (pp. 621-656). Springer New York. https://doi.org/10.1007/978-1-4614-3903-5_29

Anatomical distribution of nucleoside system in the human brain and implications for therapy. / Kovács, Z.; Dobolyi, A.

Adenosine: A Key Link between Metabolism and Brain Activity. Springer New York, 2013. p. 621-656.

Research output: Chapter in Book/Report/Conference proceedingChapter

Kovács Z, Dobolyi A. Anatomical distribution of nucleoside system in the human brain and implications for therapy. In Adenosine: A Key Link between Metabolism and Brain Activity. Springer New York. 2013. p. 621-656 https://doi.org/10.1007/978-1-4614-3903-5_29
Kovács, Z. ; Dobolyi, A. / Anatomical distribution of nucleoside system in the human brain and implications for therapy. Adenosine: A Key Link between Metabolism and Brain Activity. Springer New York, 2013. pp. 621-656
@inbook{de869d8a763e4a2891916f245a060b05,
title = "Anatomical distribution of nucleoside system in the human brain and implications for therapy",
abstract = "Nucleosides have a wide range of physiological and pathophysiological roles in the human brain as modulators of a variety of neural functions. For example, adenosine, inosine, guanosine, and uridine participate in the mechanisms underlying memory, cognition, sleep, pain, depression, schizophrenia, epilepsy, Alzheimer's disease, Huntington's disease, and Parkinson's disease. Consequently, increasing attention is now being given to the specific role of nucleosides in physiological and pathological processes in the human brain. Different elements of nucleoside system, including nucleoside concentrations, metabolic enzyme activity, and expression of nucleoside transporters and receptors, may be changed under normal and pathological conditions. The alterations suggest that interlinked elements of the nucleoside system are functioning in a tightly concerted manner. Nucleoside levels, activity of nucleoside metabolic enzymes, and expression of nucleoside transporters and receptors are unevenly distributed in the brain, suggesting that nucleosides have different roles in functionally distinct human brain areas. The aim of this chapter is to summarize our present knowledge of the anatomical distribution of nucleoside system in the human brain, placing emphasis on potential therapeutic pharmacological strategies.",
keywords = "Anatomical distribution of nucleoside system, Human brain diseases and therapy, Nucleosides",
author = "Z. Kov{\'a}cs and A. Dobolyi",
year = "2013",
month = "11",
day = "1",
doi = "10.1007/978-1-4614-3903-5_29",
language = "English",
isbn = "9781461439035",
pages = "621--656",
booktitle = "Adenosine: A Key Link between Metabolism and Brain Activity",
publisher = "Springer New York",

}

TY - CHAP

T1 - Anatomical distribution of nucleoside system in the human brain and implications for therapy

AU - Kovács, Z.

AU - Dobolyi, A.

PY - 2013/11/1

Y1 - 2013/11/1

N2 - Nucleosides have a wide range of physiological and pathophysiological roles in the human brain as modulators of a variety of neural functions. For example, adenosine, inosine, guanosine, and uridine participate in the mechanisms underlying memory, cognition, sleep, pain, depression, schizophrenia, epilepsy, Alzheimer's disease, Huntington's disease, and Parkinson's disease. Consequently, increasing attention is now being given to the specific role of nucleosides in physiological and pathological processes in the human brain. Different elements of nucleoside system, including nucleoside concentrations, metabolic enzyme activity, and expression of nucleoside transporters and receptors, may be changed under normal and pathological conditions. The alterations suggest that interlinked elements of the nucleoside system are functioning in a tightly concerted manner. Nucleoside levels, activity of nucleoside metabolic enzymes, and expression of nucleoside transporters and receptors are unevenly distributed in the brain, suggesting that nucleosides have different roles in functionally distinct human brain areas. The aim of this chapter is to summarize our present knowledge of the anatomical distribution of nucleoside system in the human brain, placing emphasis on potential therapeutic pharmacological strategies.

AB - Nucleosides have a wide range of physiological and pathophysiological roles in the human brain as modulators of a variety of neural functions. For example, adenosine, inosine, guanosine, and uridine participate in the mechanisms underlying memory, cognition, sleep, pain, depression, schizophrenia, epilepsy, Alzheimer's disease, Huntington's disease, and Parkinson's disease. Consequently, increasing attention is now being given to the specific role of nucleosides in physiological and pathological processes in the human brain. Different elements of nucleoside system, including nucleoside concentrations, metabolic enzyme activity, and expression of nucleoside transporters and receptors, may be changed under normal and pathological conditions. The alterations suggest that interlinked elements of the nucleoside system are functioning in a tightly concerted manner. Nucleoside levels, activity of nucleoside metabolic enzymes, and expression of nucleoside transporters and receptors are unevenly distributed in the brain, suggesting that nucleosides have different roles in functionally distinct human brain areas. The aim of this chapter is to summarize our present knowledge of the anatomical distribution of nucleoside system in the human brain, placing emphasis on potential therapeutic pharmacological strategies.

KW - Anatomical distribution of nucleoside system

KW - Human brain diseases and therapy

KW - Nucleosides

UR - http://www.scopus.com/inward/record.url?scp=84879399892&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84879399892&partnerID=8YFLogxK

U2 - 10.1007/978-1-4614-3903-5_29

DO - 10.1007/978-1-4614-3903-5_29

M3 - Chapter

AN - SCOPUS:84879399892

SN - 9781461439035

SN - 1461439027

SN - 9781461439028

SP - 621

EP - 656

BT - Adenosine: A Key Link between Metabolism and Brain Activity

PB - Springer New York

ER -