Anandamide (endogen cannabinoid) decreases serum prolactin level in pregnant rat

P. Giannikou, N. Yiannakakis, G. Fragkakis, K. Probonas, T. Wenger

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The putative endogenous ligand for the cannabinoid receptor, the arachyidonylethanolamide (ANA) has recently been identified and provided us the opportunity to investigate its effects on the prolactin (PRL) synthesis in pregnant rats. We compared the effects of ANA with the effects of the main psychoactive component of marihuana, the Δ9-tetrahydrocannabinol (THC) on PRL secretion. Both ANA and THC were injected i.p. daily in a dose of 0.02 mg/kg b.w. over the third week of gestation. Pituitary and serum PRL content was measured by RIA. THC caused an increase of pituitary PRL content while ANA diminished it. Serum PRL, was decreased after both ANA and THC administration. We conclude that ANA affects serum PRL level alike, but at pituitary level their action is different.

Original languageEnglish
Pages (from-to)281-287
Number of pages7
JournalNeuroendocrinology Letters
Volume17
Issue number4
Publication statusPublished - 1995

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Cannabinoids
Prolactin
Dronabinol
Serum
Cannabinoid Receptors
Cannabis
anandamide
Ligands
Pregnancy

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)

Cite this

Giannikou, P., Yiannakakis, N., Fragkakis, G., Probonas, K., & Wenger, T. (1995). Anandamide (endogen cannabinoid) decreases serum prolactin level in pregnant rat. Neuroendocrinology Letters, 17(4), 281-287.

Anandamide (endogen cannabinoid) decreases serum prolactin level in pregnant rat. / Giannikou, P.; Yiannakakis, N.; Fragkakis, G.; Probonas, K.; Wenger, T.

In: Neuroendocrinology Letters, Vol. 17, No. 4, 1995, p. 281-287.

Research output: Contribution to journalArticle

Giannikou, P, Yiannakakis, N, Fragkakis, G, Probonas, K & Wenger, T 1995, 'Anandamide (endogen cannabinoid) decreases serum prolactin level in pregnant rat', Neuroendocrinology Letters, vol. 17, no. 4, pp. 281-287.
Giannikou, P. ; Yiannakakis, N. ; Fragkakis, G. ; Probonas, K. ; Wenger, T. / Anandamide (endogen cannabinoid) decreases serum prolactin level in pregnant rat. In: Neuroendocrinology Letters. 1995 ; Vol. 17, No. 4. pp. 281-287.
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