Anandamide (endogen cannabinoid) affects anterior pituitary hormone secretion in adult male rat

T. Wenger, G. Fragakis, K. Probonas, B. E. Toth, N. Yiannakakis

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Abstract

The recent identification and purification of anandamide (arachidonyl ethanol-amide) (ANA), the putative endogenous ligand for the cannabinoid receptor provided us the chance to investigate its effects on pituitary hormone secretion. We compared the effects of Δ9-tetrahydrocannabinol (THC), the main psychoactive component of the marihuana with ANA after chronic i.p. administration in adult male rats. Both drugs altered serum levels of luteinizing hormone, follicle stimulating hormone, prolactin and growth hormone. Their effects seemed to be mainly inhibitory.

Original languageEnglish
Pages (from-to)297-303
Number of pages7
JournalNeuroendocrinology Letters
Volume16
Issue number5-6
Publication statusPublished - Dec 1 1994

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ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems
  • Clinical Neurology
  • Psychiatry and Mental health

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