Analysis of the spread of acetylcholine-induced seizures

I. Szirmai, R. Vollmer, P. Rappelsberger, R. Lapins

Research output: Contribution to journalArticle

Abstract

Cortical EEG activity during ACh-induced seizures in rabbits was analyzed in order to quantify the spatiotemporal behavior of spread of the epileptic disturbance. This process can be characterized by a slow displacement (3-6 mm/min) of epileptic excitation with shape and frequency similar to the primary focus. By measuring the degree of similarity of curves at adjacent electrodes and the power spectra it was shown that the primary discharges (10-14 Hz) were restricted to a relatively small cortical area with a radius of under 2 mm. A subsequent enlargement of the active zone is paralleled by a mostly discontinuous frequency reduction. Coherence measurements between the activities of adjacent cortical areas suggested a dependence of coherence values on both the distance of these rgions and the degree of epileptic involvement. Cross-correlation analysis showed that the discharges of these regions which later become involved in the epileptic seizure generally lead by about 14-30 ms, as compared with regions a few mm closer to the primary focus. Thus, it is suggested that during the spread of epileptic activity a slow displacement of an active zone takes place.

Original languageEnglish
JournalElectroencephalography and Clinical Neurophysiology
Volume43
Issue number4
Publication statusPublished - 1977

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Acetylcholine
Electroencephalography
Epilepsy
Electrodes
Seizures
Rabbits

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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Analysis of the spread of acetylcholine-induced seizures. / Szirmai, I.; Vollmer, R.; Rappelsberger, P.; Lapins, R.

In: Electroencephalography and Clinical Neurophysiology, Vol. 43, No. 4, 1977.

Research output: Contribution to journalArticle

Szirmai, I. ; Vollmer, R. ; Rappelsberger, P. ; Lapins, R. / Analysis of the spread of acetylcholine-induced seizures. In: Electroencephalography and Clinical Neurophysiology. 1977 ; Vol. 43, No. 4.
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