The hippocampal formation has been suggested to be a key brain structure demonstrating neuroanatomical alterations in schizophrenia. In the current study, the relative number of pyramidal neurons and calretinin-expressing interneurons of the left and right hemispheric hippocampal formation of schizophrenics (n=18) and control subjects (n=17) was determined. Most of the calretinin-staining neurons were observed in CA1 and subiculum. The number of pyramidal neurons did not differ in any of the areas examined. The same holds true for the ratio of calretinin-expressing interneurons and pyramidal neurons in all areas in the left and most areas of the right hippocampus. Only in area CA2/3 of the right hippocampus an increased ratio of calretinin- expressing interneurons and pyramidal neurons was found in schizophrenia. Despite this region specific effect in area CA2/3, the presented results suggest that there is no overall difference in the number of the calretinin class of interneurons in schizophrenia.
|Number of pages||4|
|Journal||Neurology Psychiatry and Brain Research|
|Publication status||Published - Dec 1 1999|
ASJC Scopus subject areas
- Clinical Neurology
- Psychiatry and Mental health