Analysis of the oxidative stress response of Penicillium chrysogenum to menadione

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

The intracellular superoxide and glutathione disulphide concentrations increased in Penicillium chrysogeum treated with 50, 250 or 500 μM menadione (MQ). A significant increase in the intracellular peroxide concentration was also observed when mycelia were exposed to 250 or 500 μM MQ. The specific activity of Cu,Zn and Mn superoxide dismutases, glutathione reductase and glutathione S-transferase as well as the glutathione producing activity increased in the presence of MQ while glutathione peroxidase and γ-glutamyltranspeptidase were only induced by high intracellular peroxide levels. The glucose-6-phosphate dehydrogenase and catalase activities did not respond to the oxidative stress caused by MQ.

Original languageEnglish
Pages (from-to)125-132
Number of pages8
JournalFree Radical Research
Volume30
Issue number2
Publication statusPublished - 1999

Fingerprint

Penicillium chrysogenum
Vitamin K 3
Oxidative stress
Peroxides
Oxidative Stress
Glutathione Disulfide
Glutathione Reductase
Glucosephosphate Dehydrogenase
Penicillium
Mycelium
Glutathione Peroxidase
Glutathione Transferase
Superoxides
Catalase
Superoxide Dismutase
Glutathione
Superoxide Dismutase-1

Keywords

  • Glucose-6-phosphate dehydrogenase
  • Glutathione
  • Menadione
  • Oxidative stress
  • Penicillium chrysogenum
  • Superoxide dismutase

ASJC Scopus subject areas

  • Biochemistry

Cite this

Analysis of the oxidative stress response of Penicillium chrysogenum to menadione. / Emri, T.; Pócsi, I.; Szentirmai, A.

In: Free Radical Research, Vol. 30, No. 2, 1999, p. 125-132.

Research output: Contribution to journalArticle

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