Analysis of the first complete genome sequence of an Old World monkey adenovirus reveals a lineage distinct from the six human adenovirus species

Gábor M. Kovács, Andrew J. Davison, Alexender N. Zakhartchouk, Balázs Harrach

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Simian adenovirus 3 (SAdV-3) is one of several adenoviruses that were isolated decades ago from Old World monkeys. Determination of the complete DNA sequence of SAdV-3 permitted the first full genomic comparison of a monkey adenovirus with adenoviruses of humans (HAdVs) and chimpanzees, which are recognized formally as constituting six of the species (HAdV-A to HAdV-F) within the genus Mastadenovirus. The SAdV-3 genome is 34 246 bp in size and has a G + C content of 55.3 mol%. It contains all the genes that are characteristic of the genus Mastadenovirus and has a single VA-RNA gene and six genes in each of the E3 and E4 regions. The genetic organization is the same as that of HAdV-1 2, a member of the HAdV-A species. Phylogenetic analyses showed that although SAdV-3 is related marginally more closely to HAdV-A and HAdV-F than to other species, it represents a unique lineage that branched at an early stage of primate adenovirus divergence. The results imply that the genetic layout in SAdV-3 and HAdV-1 2 may also have characterized the common ancestor of all sequenced primate adenoviruses.

Original languageEnglish
Pages (from-to)2799-2807
Number of pages9
JournalJournal of General Virology
Volume85
Issue number10
DOIs
Publication statusPublished - Oct 1 2004

ASJC Scopus subject areas

  • Virology

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