A pilocarpin hatékonyságágak elemzése a xerostomia kezelésében.

Translated title of the contribution: Analysis of the effectiveness of pilocarpine in the management of xerostomia

T. Zelles, J. Blazsek, E. Kelemen

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The authors have studied the "sympathetic like" side effect of pilocarpine after single injection (1 mg/100 g b.w., i.p.) of the drug. They developed a system for the continuous automatic recording the amylase activity of the saliva secreted by the parotid glands of rats, "in situ". Pilocarpine stimulus was characterized by a peak in amylase activity--regularly observed in the first 40-60 min--which was additive to the cholinergic amylase secretory response. After this the amylase secretion was continued with lower activity. The role of a beta-adrenergic component in the pilocarpine stimulus appears to be supported by the finding that propranolol (2.5 mg/100 g b.w., i.p.) pretreatment applied 30 min prior to the pilocarpine stimulus prevented the appearance of the characteristic amylase peak. These data support that the beta-adrenergic side effect triggering the periodical synthesis of export proteins during the course of pilocarpine treatment accounts for the selative efficiency of pilocarpine in the therapy of xerostomia.

Original languageHungarian
Pages (from-to)319-321
Number of pages3
JournalFogorvosi szemle
Volume83
Issue number9-10
Publication statusPublished - Sep 1 1990

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ASJC Scopus subject areas

  • Medicine(all)

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