Analysis of the Complete Nucleotide Sequences of Goose and Muscovy Duck Pervoviruses Indicates Common Ancestral Origin with Adeno-Associated Virus 2

Z. Zádori, Raymund Stefancsik, Tibor Rauch, János Kisary

Research output: Contribution to journalArticle

132 Citations (Scopus)

Abstract

The complete nucleotide sequences of two parvoviruses isolated from goose and muscovy duck were determined. The two virus genomes share 81.9% nucleotide sequence identity, indicating that they are closely related. The coding regions are bracketed by inverted terminal repeats containing palindromes. This is similar to the genome organization of human pervoviruses, adeno-associated virus 2, and B19. Amino acid sequence comparison shows that the closest relative of the goose and muscovy duck pervoviruses is adeno-associated virus 2. This is surprising, because the goose and muscovy duck parvoviruses do not require any helper virus for productive replication, suggesting that adeno-associated virus 2 has been derived from a helper-independent ancestor.

Original languageEnglish
Pages (from-to)562-573
Number of pages12
JournalVirology
Volume212
Issue number2
DOIs
Publication statusPublished - Oct 1 1995

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Geese
Dependovirus
Ducks
Parvovirus
Helper Viruses
Terminal Repeat Sequences
Human Genome
Virus Replication
Amino Acid Sequence
Genome
Viruses

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Analysis of the Complete Nucleotide Sequences of Goose and Muscovy Duck Pervoviruses Indicates Common Ancestral Origin with Adeno-Associated Virus 2. / Zádori, Z.; Stefancsik, Raymund; Rauch, Tibor; Kisary, János.

In: Virology, Vol. 212, No. 2, 01.10.1995, p. 562-573.

Research output: Contribution to journalArticle

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