Analysis of submicron-sized niflumic acid crystals prepared by electrospray crystallization

Rita Ambrus, Norbert Radacsi, Tímea Szunyogh, Antoine E M van der Heijden, Joop H. ter Horst, P. Szabó-Révész

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Interest in submicron-sized drug particles has emerged from both laboratory and industrial perspectives in the last decade. Production of crystals in the nano size scale offers a novel way to particles for drug formulation solving formulation problems of drugs with low solubility in class II of the Biopharmaceutical Classification System. In this work niflumic acid nanoparticles with a size range of 200-800. nm were produced by the novel crystallization method, electrospray crystallization. Their properties were compared to those from evaporative and anti-solvent crystallizations, using the same organic solvent, acetone. There is a remarkable difference in the product crystal size depending on the applied methods. The size and morphology were analyzed by scanning electron microscopy and laser diffraction. The structure of the samples was investigated using differential scanning calorimetry, Fourier-transformed infrared spectroscopy and X-ray powder diffraction. The particles produced using electrospray crystallization process were probably changing from amorphous to crystalline state after the procedure.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalJournal of Pharmaceutical and Biomedical Analysis
Volume76
DOIs
Publication statusPublished - Mar 5 2013

Fingerprint

Niflumic Acid
Crystallization
Drug Compounding
Crystals
Powder Diffraction
Differential Scanning Calorimetry
Acetone
Transmission Electron Microscopy
X-Ray Diffraction
Pharmaceutical Preparations
Electron Scanning Microscopy
Nanoparticles
X ray powder diffraction
Solubility
Organic solvents
Differential scanning calorimetry
Infrared spectroscopy
Spectrum Analysis
Lasers
Research Design

Keywords

  • Anti-solvent crystallization
  • Electrospray crystallization
  • Nanoparticles
  • Niflumic acid
  • Physico-chemical analysis
  • Solvent evaporation

ASJC Scopus subject areas

  • Analytical Chemistry
  • Drug Discovery
  • Pharmaceutical Science
  • Spectroscopy
  • Clinical Biochemistry

Cite this

Analysis of submicron-sized niflumic acid crystals prepared by electrospray crystallization. / Ambrus, Rita; Radacsi, Norbert; Szunyogh, Tímea; van der Heijden, Antoine E M; ter Horst, Joop H.; Szabó-Révész, P.

In: Journal of Pharmaceutical and Biomedical Analysis, Vol. 76, 05.03.2013, p. 1-7.

Research output: Contribution to journalArticle

Ambrus, Rita ; Radacsi, Norbert ; Szunyogh, Tímea ; van der Heijden, Antoine E M ; ter Horst, Joop H. ; Szabó-Révész, P. / Analysis of submicron-sized niflumic acid crystals prepared by electrospray crystallization. In: Journal of Pharmaceutical and Biomedical Analysis. 2013 ; Vol. 76. pp. 1-7.
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