Analysis of stability to cheaters in models of antibiotic degrading microbial communities

András Szilágyi, Gergely Boza, I. Scheuring

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Antibiotic resistance carried out by antibiotic degradation has been suggested recently as a new mechanism to maintain coexistence of microbial species competing on a single limiting resource, even in well-mixed homogeneous environments. Species diversity and community stability, however, critically depend on resistance against social cheaters, mutants that do not invest in production, but still enjoy the benefits provided by others. Here we investigate how different mutant cheaters affect the stability of antibiotic producing and degrading microbial communities. We consider two cheater types, production and degradation cheaters. We generalize the mixed inhibition-zone and chemostat models introduced previously [Kelsic, E. D., Zhao, J., Vetsigian, K., Kishony, R., 2015. Counteraction of an tibiotic production and degradation stabilizes microbial communities. Nature 521, 516–519.] to study the population dynamics of microbial communities in well-mixed environment, and analyze the invasion of different cheaters in these models. We show that production cheaters, mutants that cease producing antibiotics, always destroy coexistence whenever there is a cost of producing these antibiotics. Degradation cheaters, mutants that loose their function of producing extracellular antibiotic degrading molecules, induce community collapse only if the cost of producing the degradation factors is above a critical level. Our analytical studies, supported by numerical simulations, highlight the sensitivity of antibiotic producing and degrading communities to loss-of-function mutants.

Original languageEnglish
Pages (from-to)53-62
Number of pages10
JournalJournal of Theoretical Biology
Volume423
DOIs
Publication statusPublished - Jun 21 2017

Fingerprint

Antibiotics
microbial communities
antibiotics
Mutant
Anti-Bacterial Agents
Degradation
mutants
degradation
Coexistence
Model
Costs and Cost Analysis
Chemostat Model
Chemostats
Competing Species
Population Dynamics
Population dynamics
Microbial Drug Resistance
Biodiversity
antibiotic resistance
Invasion

Keywords

  • Antibiotic-mediated microbiome
  • Degradation resistance
  • Evolutionary instability
  • Rock-paper-scissors
  • Social parasite

ASJC Scopus subject areas

  • Statistics and Probability
  • Modelling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

Cite this

Analysis of stability to cheaters in models of antibiotic degrading microbial communities. / Szilágyi, András; Boza, Gergely; Scheuring, I.

In: Journal of Theoretical Biology, Vol. 423, 21.06.2017, p. 53-62.

Research output: Contribution to journalArticle

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