Rövidés hosszú távú túlé lés valamint a haláokok elemzés szisztémás lupus erythematosusban

Translated title of the contribution: Analysis of short-term and long-term survival and causes of death in atients with systmic lupus erythematosus

Research output: Contribution to journalArticle

Abstract

INTRODUCTION - In systemic lupus ery-thematosus (SLE), both short-term and long-term survival rates have improved worldwide. We analysed retrospectively the short-term and long-term survival data and causes of death at a single center. These data were compared with previous survival data recorded at the same centre and published in international studies. PATIENTS AND METHOD -The data of 550 patients with SLE were analysed between 1970 and 2009. We examined the effect of clinical symptoms, age, severity and onset of the disease and the applied immunosup-pressive treatment on survival, using the Kaplan-Meier method. RESULTS - Survival rates at 5, 10, 15 and 20 years after the diagnosis were 98%, 94%, 90% and 89%, respectively. Late onset, neuropsychiatric symptoms and severe SLE were found to be prognostic factors. Manifestations affecting other organs and the applied immunosuppressive therapy did not influence survival rates. During the study period, 57 out of the 550 patients (10.4%) died. The main causes of death were cardiovascular complications (50.9%), infections (21%), and malignancies (12.3%). CONCLUSIONS - Our results show that among patients with SLE, it is mostly long-term survival that has increased, owing to the close control of patients. The increase in cardiovascular mortality highlights the importance of regular screening.

Original languageHungarian
Pages (from-to)185-191
Number of pages7
JournalLege Artis Medicinae
Volume21
Issue number3
Publication statusPublished - Mar 2011

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Cause of Death
Survival
Survival Rate
Immunosuppressive Agents
Age of Onset
Mortality
Therapeutics
Infection
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

Cite this

@article{213713590a364c918ec27b7254c6abd9,
title = "R{\"o}vid{\'e}s hossz{\'u} t{\'a}v{\'u} t{\'u}l{\'e} l{\'e}s valamint a hal{\'a}okok elemz{\'e}s sziszt{\'e}m{\'a}s lupus erythematosusban",
abstract = "INTRODUCTION - In systemic lupus ery-thematosus (SLE), both short-term and long-term survival rates have improved worldwide. We analysed retrospectively the short-term and long-term survival data and causes of death at a single center. These data were compared with previous survival data recorded at the same centre and published in international studies. PATIENTS AND METHOD -The data of 550 patients with SLE were analysed between 1970 and 2009. We examined the effect of clinical symptoms, age, severity and onset of the disease and the applied immunosup-pressive treatment on survival, using the Kaplan-Meier method. RESULTS - Survival rates at 5, 10, 15 and 20 years after the diagnosis were 98{\%}, 94{\%}, 90{\%} and 89{\%}, respectively. Late onset, neuropsychiatric symptoms and severe SLE were found to be prognostic factors. Manifestations affecting other organs and the applied immunosuppressive therapy did not influence survival rates. During the study period, 57 out of the 550 patients (10.4{\%}) died. The main causes of death were cardiovascular complications (50.9{\%}), infections (21{\%}), and malignancies (12.3{\%}). CONCLUSIONS - Our results show that among patients with SLE, it is mostly long-term survival that has increased, owing to the close control of patients. The increase in cardiovascular mortality highlights the importance of regular screening.",
keywords = "Cause of death, Long-term, Survival, Systemic lupus erythematosus",
author = "T. Tarr and E. Kiss and G. Szegedi and M. Zeher",
year = "2011",
month = "3",
language = "Hungarian",
volume = "21",
pages = "185--191",
journal = "Lege Artis Medicinae",
issn = "0866-4811",
publisher = "Literatura Medica Publishing House",
number = "3",

}

TY - JOUR

T1 - Rövidés hosszú távú túlé lés valamint a haláokok elemzés szisztémás lupus erythematosusban

AU - Tarr, T.

AU - Kiss, E.

AU - Szegedi, G.

AU - Zeher, M.

PY - 2011/3

Y1 - 2011/3

N2 - INTRODUCTION - In systemic lupus ery-thematosus (SLE), both short-term and long-term survival rates have improved worldwide. We analysed retrospectively the short-term and long-term survival data and causes of death at a single center. These data were compared with previous survival data recorded at the same centre and published in international studies. PATIENTS AND METHOD -The data of 550 patients with SLE were analysed between 1970 and 2009. We examined the effect of clinical symptoms, age, severity and onset of the disease and the applied immunosup-pressive treatment on survival, using the Kaplan-Meier method. RESULTS - Survival rates at 5, 10, 15 and 20 years after the diagnosis were 98%, 94%, 90% and 89%, respectively. Late onset, neuropsychiatric symptoms and severe SLE were found to be prognostic factors. Manifestations affecting other organs and the applied immunosuppressive therapy did not influence survival rates. During the study period, 57 out of the 550 patients (10.4%) died. The main causes of death were cardiovascular complications (50.9%), infections (21%), and malignancies (12.3%). CONCLUSIONS - Our results show that among patients with SLE, it is mostly long-term survival that has increased, owing to the close control of patients. The increase in cardiovascular mortality highlights the importance of regular screening.

AB - INTRODUCTION - In systemic lupus ery-thematosus (SLE), both short-term and long-term survival rates have improved worldwide. We analysed retrospectively the short-term and long-term survival data and causes of death at a single center. These data were compared with previous survival data recorded at the same centre and published in international studies. PATIENTS AND METHOD -The data of 550 patients with SLE were analysed between 1970 and 2009. We examined the effect of clinical symptoms, age, severity and onset of the disease and the applied immunosup-pressive treatment on survival, using the Kaplan-Meier method. RESULTS - Survival rates at 5, 10, 15 and 20 years after the diagnosis were 98%, 94%, 90% and 89%, respectively. Late onset, neuropsychiatric symptoms and severe SLE were found to be prognostic factors. Manifestations affecting other organs and the applied immunosuppressive therapy did not influence survival rates. During the study period, 57 out of the 550 patients (10.4%) died. The main causes of death were cardiovascular complications (50.9%), infections (21%), and malignancies (12.3%). CONCLUSIONS - Our results show that among patients with SLE, it is mostly long-term survival that has increased, owing to the close control of patients. The increase in cardiovascular mortality highlights the importance of regular screening.

KW - Cause of death

KW - Long-term

KW - Survival

KW - Systemic lupus erythematosus

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