Analysis of research activity in gastroenterology: Pancreatitis is in real danger

Andrea Szentesi, Emese Tóth, Emese Bálint, Júlia Fanczal, Tamara Madácsy, Dorottya Laczkó, Imre Ignáth, Anita Balázs, Petra Pallagi, József Maléth, Zoltán Rakonczay, Balázs Kui, Dóra Illés, Katalin Márta, Ágnes Blaskó, Alexandra Demcsák, Andrea Párniczky, Gabriella Pár, Szilárd Gódi, Dóra MosztbacherÁkos Szücs, Adrienn Halász, Ferenc Izbéki, Nelli Farkas, Péter Hegyi

Research output: Contribution to journalArticle

14 Citations (Scopus)


Objective: Biomedical investment trends in 2015 show a huge decrease of investment in gastroenterology. Since academic research usually provides the basis for industrial research and development (R&D), our aim was to understand research trends in the field of gastroenterology over the last 50 years and identify the most endangered areas. Methods: We searched for PubMed hits for gastrointestinal (GI) diseases for the 1965±2015 period. Overall, 1,554,325 articles were analyzed. Since pancreatology was identified as the most endangered field of research within gastroenterology, we carried out a detailed evaluation of research activity in pancreatology Results: In 1965, among the major benign GI disorders, 51.9% of the research was performed on hepatitis, 25.7% on pancreatitis, 21.7% on upper GI diseases and only 0.7% on the lower GI disorders. Half a century later, in 2015, research on hepatitis and upper GI diseases had not changed significantly; however, studies on pancreatitis had dropped to 10.7%, while work on the lower GI disorders had risen to 23.4%. With regard to the malignant disorders (including liver, gastric, colon, pancreatic and oesophageal cancer), no such large-scale changes were observed in the last 50 years. Detailed analyses revealed that besides the drop in research activity in pancreatitis, there are serious problems with the quality of the studies as well. Only 6.8% of clinical trials on pancreatitis were registered and only 5.5% of these registered trials were multicentre and multinational (more than five centres and nations), i.e., the kind that provides the highest level of impact and evidence level. Conclusions: There has been a clear drop in research activity in pancreatitis. New international networks and far more academic R&D activities should be established in order to find the first therapy specifically for acute pancreatitis.

Original languageEnglish
Article numbere0165244
JournalPloS one
Issue number10
Publication statusPublished - Oct 2016

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Fingerprint Dive into the research topics of 'Analysis of research activity in gastroenterology: Pancreatitis is in real danger'. Together they form a unique fingerprint.

  • Cite this

    Szentesi, A., Tóth, E., Bálint, E., Fanczal, J., Madácsy, T., Laczkó, D., Ignáth, I., Balázs, A., Pallagi, P., Maléth, J., Rakonczay, Z., Kui, B., Illés, D., Márta, K., Blaskó, Á., Demcsák, A., Párniczky, A., Pár, G., Gódi, S., ... Hegyi, P. (2016). Analysis of research activity in gastroenterology: Pancreatitis is in real danger. PloS one, 11(10), [e0165244].