Analysis of pyridinium aldoximes - A chromatographic approach

T. Csermely, Huba Kalász, G. A. Petroianu, K. Kuca, F. Darvas, K. Ludányi, A. A. Mudhafar, K. Tekes

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

Pyridinium aldoximes are used as antidotes to organophosphorus cholinesterase inhibitors. All pyridinium aldoximes (oximes) are highly polar quaternary ammonium compounds showing low to minimal blood-brain-barrier (BBB) penetration. Oximes are separated using reversed-phase (RP) HPLC methods and/or thin-layer chromatography (TLC). The chemical structures, elementary compositions, molecular sizes and the calculated logP values of several mono- and bis-pyridinium aldoximes are given. Chromatographic and electrophoretic analyses of oximes are detailed, including the stationary and mobile phase composition and the mode of detection. Degradation pathways and products are also discussed. To characterize oximes lipophilicity/hydrophilicity an in silico method was used and expanded as to describe organophosphorus compound adducts with several pyridinium aldoximes.

Original languageEnglish
Pages (from-to)2401-2418
Number of pages18
JournalCurrent medicinal chemistry
Volume15
Issue number23
DOIs
Publication statusPublished - Dec 15 2008

Keywords

  • Blood
  • Blood-brain-barrier penetration HPLC
  • Chromatography
  • Lipophilicity
  • Pyridinium aldoximes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Analysis of pyridinium aldoximes - A chromatographic approach'. Together they form a unique fingerprint.

  • Cite this