Analysis of oral yeast microflora in patients with oral squamous cell carcinoma

Csaba Berkovits, Adél Tóth, Judit Szenzenstein, Tünde Deák, E. Urbán, A. Gácser, K. Nagy

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Oral squamous cell carcinoma (OSCC) is the most common form of oral cancer, in this study, the association between OSCC and oral yeast carriage was investigated. Findings: 20 patients having OSCC as well as 40 healthy controls were tested for the presence of yeasts in the oral cavity. Fungal burdens were examined by colony forming unit determinations, while the different yeast genera in patient samples were identified by matrix-associated laser desorption/ionization-time of flight-mass spectrometry. We found that the level of oral yeast carriage was significantly higher in patients with OSCC that was accompanied by a higher diversity of yeasts in the oral cavity of these patients. We also examined the extracellular enzyme production of isolated Candida spp.; however, we found that there was no association between the lipase/protease producing capacity of Candida strains and the higher colonisation rate of neoplastic epithelium. Conclusions: In conclusion, our results corroborate the findings of previous studies regarding the association between oral yeast carriage and epithelial carcinoma.

Original languageEnglish
Article number1257
JournalSpringerPlus
Volume5
Issue number1
DOIs
Publication statusPublished - Dec 1 2016

Fingerprint

Squamous Cell Carcinoma
Yeasts
Candida
Mouth
Mouth Neoplasms
Lipase
Mass Spectrometry
Lasers
Peptide Hydrolases
Stem Cells
Epithelium
Carcinoma
Enzymes

Keywords

  • Candida
  • MALDI-TOF
  • Oral squamous cell carcinoma
  • Yeast

ASJC Scopus subject areas

  • General

Cite this

Analysis of oral yeast microflora in patients with oral squamous cell carcinoma. / Berkovits, Csaba; Tóth, Adél; Szenzenstein, Judit; Deák, Tünde; Urbán, E.; Gácser, A.; Nagy, K.

In: SpringerPlus, Vol. 5, No. 1, 1257, 01.12.2016.

Research output: Contribution to journalArticle

Berkovits, Csaba ; Tóth, Adél ; Szenzenstein, Judit ; Deák, Tünde ; Urbán, E. ; Gácser, A. ; Nagy, K. / Analysis of oral yeast microflora in patients with oral squamous cell carcinoma. In: SpringerPlus. 2016 ; Vol. 5, No. 1.
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