Analysis of niflumic acid prepared by rapid microwave-assisted evaporation

Norbert Radacsi, Georgios D. Stefanidis, P. Szabó-Révész, Rita Ambrus

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Evaporative crystallization is widely applied in several industrial processes, including the pharmaceutical industry. Microwave irradiation can significantly speed up solvent evaporation in these crystallization processes, resulting in reduced particle size due to rapid crystallization. A single-mode microwave setup was used for evaporative crystallization of the model active pharmaceutical ingredient, niflumic acid, and the polymer, polyvinylpirrolidone (PVP). Production of crystals by microwave irradiation offers a modern way for drug formulation, and by reducing the particle size the dissolution rate and bioavailability of the active pharmaceutical ingredient can be enhanced. In this study, a 2.5-fold increase in the dissolution rate of the produced niflumic acid crystals was observed compared to the dissolution rate of the original drug in 120. min. When niflumic acid was produced together with the PVP in the microwave system, an amorphous solid dispersion was created with particles in the nano-size range, which showed a 5-fold increase in dissolution rate in 120. min compared to the dissolution of the crystalline niflumic acid samples created by the microwave irradiation in the absence of PVP.

Original languageEnglish
Pages (from-to)16-21
Number of pages6
JournalJournal of Pharmaceutical and Biomedical Analysis
Volume98
DOIs
Publication statusPublished - 2014

Fingerprint

Niflumic Acid
Microwaves
Crystallization
Dissolution
Evaporation
Microwave irradiation
Particle Size
Pharmaceutical Preparations
Particle size
Drug Compounding
Crystals
Drug Industry
Biological Availability
Polymers
Crystalline materials
Industry

Keywords

  • Amorphous solid dispersion
  • Evaporative crystallization
  • Microwave
  • Niflumic acid
  • Physico-chemical analysis

ASJC Scopus subject areas

  • Analytical Chemistry
  • Drug Discovery
  • Pharmaceutical Science
  • Spectroscopy
  • Clinical Biochemistry
  • Medicine(all)

Cite this

Analysis of niflumic acid prepared by rapid microwave-assisted evaporation. / Radacsi, Norbert; Stefanidis, Georgios D.; Szabó-Révész, P.; Ambrus, Rita.

In: Journal of Pharmaceutical and Biomedical Analysis, Vol. 98, 2014, p. 16-21.

Research output: Contribution to journalArticle

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