Analysis of inclusion complexes of clotrimazole and differently substituted α, β and γ cyclodextrins by NMR spectroscopy

Hajnal Kelemen, Bela Noszal, Gabor Orgovan

Research output: Contribution to journalArticle

Abstract

Clotrimazole, a widely used imidazole-type antifungal agent and its cyclodextrin complexes were studied. Stoichiometries, structures and stability constants of the inclusion complexes with fourteen different cyclodextrin derivatives were characterized using NMR spectroscopy as primary technique. The cyclodextrin complexes were found to be of high stability (logK > 2). 2D ROESY NMR spectra revealed the formation of isomeric complexes with every cyclodextrin studied. The highest stability constant was observed with sulfobutylated β-CD, and interestingly enough the heptakis(2,3,6tri-O-methyl)-β-cyclodextrin showed the lowest stability.

Original languageEnglish
Pages (from-to)497-506
Number of pages10
JournalRevista de Chimie
Volume71
Issue number3
DOIs
Publication statusPublished - Mar 1 2020

Keywords

  • Clotriomazole
  • Cyclodextrin
  • Inclusion complex
  • NMR
  • Stability

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science (miscellaneous)
  • Engineering(all)
  • Surfaces, Coatings and Films
  • Materials Chemistry

Fingerprint Dive into the research topics of 'Analysis of inclusion complexes of clotrimazole and differently substituted α, β and γ cyclodextrins by NMR spectroscopy'. Together they form a unique fingerprint.

  • Cite this