Analysis of hormonal changes during combined buserelin/HMG treatment

J. Urbancsek, Thomas Rabe, Klaus Grunwald, Ludwig Kiesel, Benno Runnebaum

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Changes of serum oestradiol, LH and progesterone have been analysed in view of the effect of the GnRH analogue buserelin on the late follicular and early luteal phase of cycles stimulated with combined buserelin/HMG (n = 31) in an IVF-ET/GIFT programme. Patients undergoing cycles with HMG only (n = 57) served as the control group. With the use of the GnRH analogue buserelin, a significantly higher amount of HMG (25 versus 20 ampoules; P <0.001) for a significantly longer stimulation period (10 versus 8 days; P <0.001) was necessary to achieve the same oestradiol response as seen in HMG cycles. Serum progesterone levels during a three day period before ovulation induction tended to be lower in the combined buserelin/HMG cycles than in cycles with HMG stimulation only. We did not observe any significant difference in the luteal phase progesterone levels of the buserelin/HMG and the HMG group. On the other hand, we found that an inadequate luteal phase in buserelin/HMG cycles could be avoided by HCG administration during the luteal phase. Both the elevation of basal serum LH and a premature LH rise could also be avoided by the use of buserelin.

Original languageEnglish
Pages (from-to)675-681
Number of pages7
JournalHuman Reproduction
Volume5
Issue number6
Publication statusPublished - Aug 1990

Fingerprint

Buserelin
Luteal Phase
Cycle
Progesterone
Estradiol
Gonadotropin-Releasing Hormone
Therapeutics
Ovulation Induction
Analogue
Serum
Necessary
Control Groups

Keywords

  • GIFT
  • GnRH analogue
  • IVF-ET
  • LH
  • Oestradiol
  • Progesterone

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Reproductive Medicine
  • Obstetrics and Gynaecology
  • Rehabilitation
  • Physiology
  • Developmental Biology

Cite this

Urbancsek, J., Rabe, T., Grunwald, K., Kiesel, L., & Runnebaum, B. (1990). Analysis of hormonal changes during combined buserelin/HMG treatment. Human Reproduction, 5(6), 675-681.

Analysis of hormonal changes during combined buserelin/HMG treatment. / Urbancsek, J.; Rabe, Thomas; Grunwald, Klaus; Kiesel, Ludwig; Runnebaum, Benno.

In: Human Reproduction, Vol. 5, No. 6, 08.1990, p. 675-681.

Research output: Contribution to journalArticle

Urbancsek, J, Rabe, T, Grunwald, K, Kiesel, L & Runnebaum, B 1990, 'Analysis of hormonal changes during combined buserelin/HMG treatment', Human Reproduction, vol. 5, no. 6, pp. 675-681.
Urbancsek J, Rabe T, Grunwald K, Kiesel L, Runnebaum B. Analysis of hormonal changes during combined buserelin/HMG treatment. Human Reproduction. 1990 Aug;5(6):675-681.
Urbancsek, J. ; Rabe, Thomas ; Grunwald, Klaus ; Kiesel, Ludwig ; Runnebaum, Benno. / Analysis of hormonal changes during combined buserelin/HMG treatment. In: Human Reproduction. 1990 ; Vol. 5, No. 6. pp. 675-681.
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