Analysis of genetic alterations in salivary gland tumors by comparative genomic hybridization

Makoto Toida, M. Balázs, Tomohiro Mori, Jun Ichi Ishimaru, Hideki Ichihara, Hideki Fujitsuka, Iwao Hyodo, Kyoko Yokoyama, Norichika Tatematsu, R. Ádány

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

In order to define and map chromosomal copy number alterations in salivary gland tumors (SGTs), a comparative genomic hybridization (CGH) technique was applied to two pleomorphic adenomas (PAs), one adenoid cystic carcinoma (ACC), and one basal cell adenocarcinoma (BCAC). The PAs exhibited regional copy number losses at 5q12.4-q14.1, 9q12-q21.13, and 16q11.2, as well as a gain at 20p12.1; among these, the losses at the 9q12-q21.11 and 16q11.2 regions were common to both PAs. The ACC showed overrepresentations of the entire regions of chromosomes 16 and 20, a regional gain at 22q12.3-q13.1, and no losses. In the BCAC, regional gains at 9p21.1-pter, 18q21.1-q22.3, and 22q11.23-q13.31 as well as losses at 2q24.2 and 4q25-q27 were seen; the gain at 22q12.3-q13.1 was common in both the ACC and the BCAC. These CGH data indicate that different genetic alterations are present in the different types of SGTs, and that the alterations involve several chromosomes. The discovery of common alterations in the same and/or different types of tumors might be important in the understanding of the development and progression of the SGTs.

Original languageEnglish
Pages (from-to)34-37
Number of pages4
JournalCancer Genetics and Cytogenetics
Volume127
Issue number1
DOIs
Publication statusPublished - May 2001

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Pleomorphic Adenoma
Adenoid Cystic Carcinoma
Comparative Genomic Hybridization
Glandular and Epithelial Neoplasms
Adenocarcinoma
Chromosomes, Human, Pair 20
Chromosomes, Human, Pair 16
Chromosomes
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Analysis of genetic alterations in salivary gland tumors by comparative genomic hybridization. / Toida, Makoto; Balázs, M.; Mori, Tomohiro; Ishimaru, Jun Ichi; Ichihara, Hideki; Fujitsuka, Hideki; Hyodo, Iwao; Yokoyama, Kyoko; Tatematsu, Norichika; Ádány, R.

In: Cancer Genetics and Cytogenetics, Vol. 127, No. 1, 05.2001, p. 34-37.

Research output: Contribution to journalArticle

Toida, M, Balázs, M, Mori, T, Ishimaru, JI, Ichihara, H, Fujitsuka, H, Hyodo, I, Yokoyama, K, Tatematsu, N & Ádány, R 2001, 'Analysis of genetic alterations in salivary gland tumors by comparative genomic hybridization', Cancer Genetics and Cytogenetics, vol. 127, no. 1, pp. 34-37. https://doi.org/10.1016/S0165-4608(00)00410-6
Toida, Makoto ; Balázs, M. ; Mori, Tomohiro ; Ishimaru, Jun Ichi ; Ichihara, Hideki ; Fujitsuka, Hideki ; Hyodo, Iwao ; Yokoyama, Kyoko ; Tatematsu, Norichika ; Ádány, R. / Analysis of genetic alterations in salivary gland tumors by comparative genomic hybridization. In: Cancer Genetics and Cytogenetics. 2001 ; Vol. 127, No. 1. pp. 34-37.
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