Analysis of follicle-cell functions in drosophila: The Fs(3)Apc mutation and the development of chorionic appendages

J. Szabad, Gyula Hoffmann

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Fs(3)Apc is a dominant female-sterile mutation of Drosophila melanogaster which causes an incomplete migration of follicle cells between the oocyte and the nurse cells. This leads to leakage of anterior egg cytoplasm followed by degeneration of the egg primordium or deposition of flaccid eggs with reduced anterior egg coverings including the dorsal appendages. Analysis of ovarian and germ-line chimeras revealed that the focus of the Ape phenotype is located in the ovarian soma. Apc+ clones, induced by mitotic recombination, lead to the formation of "exceptional" eggs with (often partial) rescue of the mutant phenotype. Analysis of Apc+ mosaics shows that the Apc mutant phenotype depends on the genotype of the anterior follicle cells. The patterns of apparent Apc+ clones suggest that there is no lineage restriction between the follicle cells that form the anterior egg coverings and those that form the dorsal appendages at the follicle envelope stage.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalDevelopmental Biology
Volume131
Issue number1
DOIs
Publication statusPublished - 1989

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Drosophila
Ovum
Mutation
Phenotype
Eggs
Clone Cells
Hominidae
Carisoprodol
Drosophila melanogaster
Germ Cells
Genetic Recombination
Oocytes
Cell Movement
Cytoplasm
Nurses
Genotype

ASJC Scopus subject areas

  • Developmental Biology

Cite this

Analysis of follicle-cell functions in drosophila : The Fs(3)Apc mutation and the development of chorionic appendages. / Szabad, J.; Hoffmann, Gyula.

In: Developmental Biology, Vol. 131, No. 1, 1989, p. 1-10.

Research output: Contribution to journalArticle

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