Analysis of deprenyl metabolites in some body compartments of rats using GC-MSD

D. Haberle, H. Kalász, I. Hollósi, J. Pucsok, T. Csermely, K. Magyar, E. Tóth-Molnár

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Deprenyl metabolites were analyzed in various organs of rats after chronic oral treatment. The investigation was carried out by gas chromatography combined with MSD after derivatization of the metabolites. When (-)-deprenyl (selegiline) was administered to rats higher ratios of methamphetamine to amphetamine were found in the kidney, and the heart at 1 and 5 h after treatment, than after (+)-deprenyl administration. Both deprenyl and its demethylated metabolite were also detected; however, their level was generally lower than that of either methamphetamine or amphetamine. Coadministration of verapamil with selegiline did not essentially alter the major metabolic pathway of deprenyl metabolism.

Original languageEnglish
Pages (from-to)415-422
Number of pages8
JournalChromatographia
Volume50
Issue number7-8
Publication statusPublished - Oct 1999

Fingerprint

Selegiline
Metabolites
Rats
Methamphetamine
Amphetamine
Verapamil
Metabolic Networks and Pathways
Metabolism
Gas chromatography
Gas Chromatography
Kidney

Keywords

  • Deprenyl metabolites
  • Deprenyl- verapamyl coadministration
  • Gas chromatography - mass spectrometry
  • Kidney and heart samples

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Analytical Chemistry

Cite this

Haberle, D., Kalász, H., Hollósi, I., Pucsok, J., Csermely, T., Magyar, K., & Tóth-Molnár, E. (1999). Analysis of deprenyl metabolites in some body compartments of rats using GC-MSD. Chromatographia, 50(7-8), 415-422.

Analysis of deprenyl metabolites in some body compartments of rats using GC-MSD. / Haberle, D.; Kalász, H.; Hollósi, I.; Pucsok, J.; Csermely, T.; Magyar, K.; Tóth-Molnár, E.

In: Chromatographia, Vol. 50, No. 7-8, 10.1999, p. 415-422.

Research output: Contribution to journalArticle

Haberle, D, Kalász, H, Hollósi, I, Pucsok, J, Csermely, T, Magyar, K & Tóth-Molnár, E 1999, 'Analysis of deprenyl metabolites in some body compartments of rats using GC-MSD', Chromatographia, vol. 50, no. 7-8, pp. 415-422.
Haberle D, Kalász H, Hollósi I, Pucsok J, Csermely T, Magyar K et al. Analysis of deprenyl metabolites in some body compartments of rats using GC-MSD. Chromatographia. 1999 Oct;50(7-8):415-422.
Haberle, D. ; Kalász, H. ; Hollósi, I. ; Pucsok, J. ; Csermely, T. ; Magyar, K. ; Tóth-Molnár, E. / Analysis of deprenyl metabolites in some body compartments of rats using GC-MSD. In: Chromatographia. 1999 ; Vol. 50, No. 7-8. pp. 415-422.
@article{16d9fe871c01422bb107faab12e053f2,
title = "Analysis of deprenyl metabolites in some body compartments of rats using GC-MSD",
abstract = "Deprenyl metabolites were analyzed in various organs of rats after chronic oral treatment. The investigation was carried out by gas chromatography combined with MSD after derivatization of the metabolites. When (-)-deprenyl (selegiline) was administered to rats higher ratios of methamphetamine to amphetamine were found in the kidney, and the heart at 1 and 5 h after treatment, than after (+)-deprenyl administration. Both deprenyl and its demethylated metabolite were also detected; however, their level was generally lower than that of either methamphetamine or amphetamine. Coadministration of verapamil with selegiline did not essentially alter the major metabolic pathway of deprenyl metabolism.",
keywords = "Deprenyl metabolites, Deprenyl- verapamyl coadministration, Gas chromatography - mass spectrometry, Kidney and heart samples",
author = "D. Haberle and H. Kal{\'a}sz and I. Holl{\'o}si and J. Pucsok and T. Csermely and K. Magyar and E. T{\'o}th-Moln{\'a}r",
year = "1999",
month = "10",
language = "English",
volume = "50",
pages = "415--422",
journal = "Chromatographia",
issn = "0009-5893",
publisher = "Springer Vieweg",
number = "7-8",

}

TY - JOUR

T1 - Analysis of deprenyl metabolites in some body compartments of rats using GC-MSD

AU - Haberle, D.

AU - Kalász, H.

AU - Hollósi, I.

AU - Pucsok, J.

AU - Csermely, T.

AU - Magyar, K.

AU - Tóth-Molnár, E.

PY - 1999/10

Y1 - 1999/10

N2 - Deprenyl metabolites were analyzed in various organs of rats after chronic oral treatment. The investigation was carried out by gas chromatography combined with MSD after derivatization of the metabolites. When (-)-deprenyl (selegiline) was administered to rats higher ratios of methamphetamine to amphetamine were found in the kidney, and the heart at 1 and 5 h after treatment, than after (+)-deprenyl administration. Both deprenyl and its demethylated metabolite were also detected; however, their level was generally lower than that of either methamphetamine or amphetamine. Coadministration of verapamil with selegiline did not essentially alter the major metabolic pathway of deprenyl metabolism.

AB - Deprenyl metabolites were analyzed in various organs of rats after chronic oral treatment. The investigation was carried out by gas chromatography combined with MSD after derivatization of the metabolites. When (-)-deprenyl (selegiline) was administered to rats higher ratios of methamphetamine to amphetamine were found in the kidney, and the heart at 1 and 5 h after treatment, than after (+)-deprenyl administration. Both deprenyl and its demethylated metabolite were also detected; however, their level was generally lower than that of either methamphetamine or amphetamine. Coadministration of verapamil with selegiline did not essentially alter the major metabolic pathway of deprenyl metabolism.

KW - Deprenyl metabolites

KW - Deprenyl- verapamyl coadministration

KW - Gas chromatography - mass spectrometry

KW - Kidney and heart samples

UR - http://www.scopus.com/inward/record.url?scp=0033209579&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033209579&partnerID=8YFLogxK

M3 - Article

VL - 50

SP - 415

EP - 422

JO - Chromatographia

JF - Chromatographia

SN - 0009-5893

IS - 7-8

ER -