Analysis of cortico-subcortical seizure potentials in relation to regional cortical blood flow

I. Szirmai, J. Czopf

Research output: Contribution to journalArticle

Abstract

Spreading epileptiform seizures were provoked by topical application of acetylcholine on the cortex of rabbits. EEG and regional cortical blood flow (recorded by heated thermistors) were compared. Propagation of seizure discharges was estimated on the basis of time differences of the corresponding cortico-cortical and cortico-mesencephalic potentials. With focal and spreading seizures accompanied by a decrease of regional cortical blood flow, the spikes were generated 8-12 msec sooner in the primary cortical focus than in the mesencephalon. With generalized seizures accompanied by an increase of regional cortical blood flow, synmorphic rhythmic discharges appeared on the cortical and mesencephalic records and the time-differences of the seizure potentials changed to opposite. Possibilities of the localisation of cortical and subcortical trigger areas by measuring the time differences and power-spectra of seizure potentials are discussed.

Original languageEnglish
Pages (from-to)317-326
Number of pages10
JournalActa Physiologica Academiae Scientiarum Hungaricae
Volume50
Issue number3
Publication statusPublished - 1977

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Regional Blood Flow
Seizures
Trigger Points
Mesencephalon
Acetylcholine
Electroencephalography
Rabbits

ASJC Scopus subject areas

  • Physiology

Cite this

Analysis of cortico-subcortical seizure potentials in relation to regional cortical blood flow. / Szirmai, I.; Czopf, J.

In: Acta Physiologica Academiae Scientiarum Hungaricae, Vol. 50, No. 3, 1977, p. 317-326.

Research output: Contribution to journalArticle

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