Analysis of co-spray-dried meloxicam-mannitol systems containing crystalline microcomposites

Anita Pomázi, Rita Ambrus, P. Sípos, P. Szabó-Révész

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The crystal size, form, wettability and rate of dissolution of a drug are factors limiting its nasal or pulmonary administration. The aim of this work was to achieve an ideal crystal habit, good wettability and the rapid release of meloxicam (MEL), a poorly water-soluble non-steroidal anti-inflammatory drug. The structures of MEL and the carrier-based systems were analysed by differential scanning calorimetry, X-ray diffractometry and Fourier transform infrared spectroscopy. The particle size and morphology were investigated by laser diffraction and SEM analyses. The novelty of this work was the use of a co-spray-drying technique, which resulted in mannitol-based crystalline microcomposites (1-6 μm) containing MEL microcrystals (1-5 μm). The particle size and form of the MEL microcrystals were adjusted by a top-down method. The presence of mannitol (with a MEL:mannitol mass ratio of 1:1) with additives ensured the homogeneous distribution of MEL in the microcomposites with good wettability and rapid release (100% MEL within 5. min).

Original languageEnglish
Pages (from-to)183-190
Number of pages8
JournalJournal of Pharmaceutical and Biomedical Analysis
Volume56
Issue number2
DOIs
Publication statusPublished - Sep 10 2011

Fingerprint

meloxicam
Mannitol
Crystalline materials
Wettability
Wetting
Microcrystals
Particle Size
Particle size
Spray drying
Crystals
Differential Scanning Calorimetry
Fourier Transform Infrared Spectroscopy
Nose
Pharmaceutical Preparations
X ray diffraction analysis
Habits
Differential scanning calorimetry
Dissolution
Lasers
Anti-Inflammatory Agents

Keywords

  • Dissolution rate
  • Microparticles
  • Morphology
  • Poorly soluble drug
  • Powder technology
  • Spray-drying

ASJC Scopus subject areas

  • Analytical Chemistry
  • Drug Discovery
  • Pharmaceutical Science
  • Spectroscopy
  • Clinical Biochemistry

Cite this

Analysis of co-spray-dried meloxicam-mannitol systems containing crystalline microcomposites. / Pomázi, Anita; Ambrus, Rita; Sípos, P.; Szabó-Révész, P.

In: Journal of Pharmaceutical and Biomedical Analysis, Vol. 56, No. 2, 10.09.2011, p. 183-190.

Research output: Contribution to journalArticle

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