β-endorphin, deltorphin II, [D-Ala2, Phe4, Gly5-ol-enkephalin (DAGO) as well as endomorphin- 1 and endomorphin-2 injected intracerebroventricularly (icv.) induced gastroprotective action. It has been raised that endogenous opioids may have a central role in maintaining gastric mucosal integrity. Therefore we aimed to study the role of endogenous opioid system in the gastroprotective action induced by activation of α2- adrenoceptors, nociceptin- and cannabinoid- receptors. Our results suggest that the non-selective opioid receptor antagonist naloxone (27 nmol icv.) and the δ-opioid receptor antagonist naltrindole (5 nmol icv.) abolished the mucosal protective effect of α2-adrenoceptor agonists clonidine (470 pmol icv.) and rilmenidine (45 pmol icv.), nociceptin (1 nmol icv.) and the cannabinoid receptor agonist anandamide (110 nmol icv.). Based on our findings it can be raised that opioid system besides its well known regulatory functions might be involved in maintenance of gastric mucosal integrity.
|Translated title of the contribution||Analysis of central mechanisms involved in gastric mucosal integrity|
|Publication status||Published - Dec 1 2008|
ASJC Scopus subject areas
- Neuropsychology and Physiological Psychology
- Pharmacology, Toxicology and Pharmaceutics(all)
- Clinical Neurology