Analysis and modulation of spike trains and oscillations in identified neural network of Lymnaea stagnalis L

G. Molnar, A. Szucs, K. S. Rozsa

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Abstract

Identified neurons and members of functionally characterized clusters of the central nervous system of Lymnaea stagnalis L. were studied. Long-term spike trains (10-100 min) were collected using current clamp method. Firing patterns were analyzed by several mathematical tools e.g.: Spike density function (SDF), interspike interval (ISI), Fourier-transform. Both the spike trains and oscillation of firing were modulated by 5HT (2 x 10-5 M) and μ-opioid peptides (10-5 M). Co-application of 5HT (2 x 10-5 M) and DAGO (10-5 M) turned the firing of the neurons (RPeD1 and A cells) opposite to the running pattern and eliminated the 0.3 Hz oscillation causing a new slow periodicity (0.1-0.05 Hz).

Original languageEnglish
Pages (from-to)231-235
Number of pages5
JournalActa biologica Hungarica
Volume51
Issue number2-4
Publication statusPublished - Sep 28 2000

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Keywords

  • 5HT
  • Lymnaea neuron
  • Network modulation
  • Opioid peptides
  • Spike trains

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Neurology

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