Analyses of a MS-associated haplotype encompassing the CCL3 gene

Tamara Vyshkina, B. Kálmán

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Our previous studies showed the association of multiple sclerosis with the same marker haplotype encompassing the CCL3 gene in two independent sets of families. Here we present that sequencing of this haplotype and its flanking regions detected no new mutation, but 16 single nucleotide polymorphisms (SNP) and 1 insertion/deletion variant in both affected and unaffected individuals. Transmission distortion analyses of the newly identified variants in the second set of families revealed no individual marker association. In the absence of a single disease relevant variant within the MS associated haplotype and the surrounding linkage disequilibrium block, the highlighted haplotype may itself indicate a functionally relevant allelic combination or interaction.

Original languageEnglish
Pages (from-to)216-218
Number of pages3
JournalJournal of Neuroimmunology
Volume176
Issue number1-2
DOIs
Publication statusPublished - Jul 2006

Fingerprint

Haplotypes
Genes
Linkage Disequilibrium
Multiple Sclerosis
Single Nucleotide Polymorphism
Mutation

Keywords

  • CCL3
  • Genetic association
  • LD mapping
  • Multiple sclerosis

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Cite this

Analyses of a MS-associated haplotype encompassing the CCL3 gene. / Vyshkina, Tamara; Kálmán, B.

In: Journal of Neuroimmunology, Vol. 176, No. 1-2, 07.2006, p. 216-218.

Research output: Contribution to journalArticle

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