Analyses of a MS-associated haplotype encompassing the CCL3 gene

Tamara Vyshkina, Bernadette Kalman

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Our previous studies showed the association of multiple sclerosis with the same marker haplotype encompassing the CCL3 gene in two independent sets of families. Here we present that sequencing of this haplotype and its flanking regions detected no new mutation, but 16 single nucleotide polymorphisms (SNP) and 1 insertion/deletion variant in both affected and unaffected individuals. Transmission distortion analyses of the newly identified variants in the second set of families revealed no individual marker association. In the absence of a single disease relevant variant within the MS associated haplotype and the surrounding linkage disequilibrium block, the highlighted haplotype may itself indicate a functionally relevant allelic combination or interaction.

Original languageEnglish
Pages (from-to)216-218
Number of pages3
JournalJournal of Neuroimmunology
Volume176
Issue number1-2
DOIs
Publication statusPublished - Jul 1 2006

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Keywords

  • CCL3
  • Genetic association
  • LD mapping
  • Multiple sclerosis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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