Analgesic nephropathy in Hungary: The HANS study

István Pintér, János Mátyus, Zoltán Czégány, Judit Harsányi, Marietta Homoki, Miklós Kassai, Éva Kiss, István Kiss, Erzsébet Ladányi, Lajos Locsey, Lajos Major, Mihály Misz, Lajos Nagy, Kálmán Polner, Jeno Rédl, István Solt, Béla Tichy, Marietta Török, Gábor Varga, Gyula WagnerImre Wórum, Béla Zsoldos, László Pótó, Katalin Dérczy, István Wittmann, Judit Nagy

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Background. The diagnosis of analgesic nephropathy has improved significantly with modern imaging techniques. We reviewed a large portion of the Hungarian dialysis population to obtain additional insight into the problem. Methods. Twenty-two participating dialysis units enrolled 1400 patients on renal replacement therapy between 1 January 1995 and 1 January 1998. Patients with no known aetiology (n=284) were interviewed and studied with renal imaging. We assessed the presence of decreased renal mass combined with either bumpy contours, papillary calcification, or both. The subjects studied were interrogated extensively. Results. Our survey suggested analgesic nephropathy in 47 of 1400 patients (3.3%), 3-fold higher than the EDTA database estimate for Hungary. The analgesics most commonly abused were phenacetin-containing mixtures. The driving symptoms were mainly headache and joint pain. Cardiovascular complications were more common than in the rest of the dialysis population, independent of smoking and lipid values (P <0.01). Conclusions. Phenacetin should be banned. Our study results support the need for longitudinal cohort and case-control studies in Hungary.

Original languageEnglish
Pages (from-to)840-843
Number of pages4
JournalNephrology Dialysis Transplantation
Volume19
Issue number4
DOIs
Publication statusPublished - Apr 1 2004

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Keywords

  • Analgesic nephropathy
  • Hungary
  • Renal replacement therapy

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

Cite this

Pintér, I., Mátyus, J., Czégány, Z., Harsányi, J., Homoki, M., Kassai, M., Kiss, É., Kiss, I., Ladányi, E., Locsey, L., Major, L., Misz, M., Nagy, L., Polner, K., Rédl, J., Solt, I., Tichy, B., Török, M., Varga, G., ... Nagy, J. (2004). Analgesic nephropathy in Hungary: The HANS study. Nephrology Dialysis Transplantation, 19(4), 840-843. https://doi.org/10.1093/ndt/gfh040