Analgesic effects of the somatostatin sst4 receptor selective agonist J-2156 in acute and chronic pain models

Katalin Sándor, Krisztián Elekes, Árpád Szabó, Erika Pintér, Mia Engström, Siegfried Wurster, János Szolcsányi, Zsuzsanna Helyes

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33 Citations (Scopus)

Abstract

Somatostatin released from capsaicin-sensitive afferents exerts systemic anti-nociceptive actions, presumably via somatostatin receptor subtype 4 (sst4). In the present study, the antinociceptive effects of a novel somatostatin sst4 receptor selective peptidomimetic compound, J-2156 (1-100 μg/kg i.p.), were examined. J-2156 inhibited nocifensive behaviour of mice in the second phase of the formalin test. Adjuvant-evoked chronic inflammatory mechanical allodynia was decreased in rats treated with J-2156 for 21 days. Sciatic nerve ligation-induced neuropathic mechanical hyperalgesia was inhibited by J-2156 on the seventh postoperative day. Results obtained using this highly selective agonist suggest that somatostatin sst4 receptors represent a promising target for new perspectives in analgesic therapy.

Original languageEnglish
Pages (from-to)71-75
Number of pages5
JournalEuropean Journal of Pharmacology
Volume539
Issue number1-2
DOIs
Publication statusPublished - Jun 6 2006

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Keywords

  • Adjuvant-induced inflammation
  • Anti-nociceptive effect
  • Formalin test
  • Somatostatin
  • Traumatic mononeuropathy

ASJC Scopus subject areas

  • Pharmacology

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