Analgesic effects of the somatostatin sst4 receptor selective agonist J-2156 in acute and chronic pain models

K. Sándor, K. Elekes, Árpád Szabó, E. Pintér, Mia Engström, Siegfried Wurster, J. Szolcsányi, Z. Helyes

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Somatostatin released from capsaicin-sensitive afferents exerts systemic anti-nociceptive actions, presumably via somatostatin receptor subtype 4 (sst4). In the present study, the antinociceptive effects of a novel somatostatin sst4 receptor selective peptidomimetic compound, J-2156 (1-100 μg/kg i.p.), were examined. J-2156 inhibited nocifensive behaviour of mice in the second phase of the formalin test. Adjuvant-evoked chronic inflammatory mechanical allodynia was decreased in rats treated with J-2156 for 21 days. Sciatic nerve ligation-induced neuropathic mechanical hyperalgesia was inhibited by J-2156 on the seventh postoperative day. Results obtained using this highly selective agonist suggest that somatostatin sst4 receptors represent a promising target for new perspectives in analgesic therapy.

Original languageEnglish
Pages (from-to)71-75
Number of pages5
JournalEuropean Journal of Pharmacology
Volume539
Issue number1-2
DOIs
Publication statusPublished - Jun 6 2006

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Acute Pain
Somatostatin
Chronic Pain
Analgesics
Hyperalgesia
Peptidomimetics
Capsaicin
Sciatic Nerve
Pain Measurement
Ligation
(1'S, 2S)-4-amino-N-(1'-carbamoyl-2'-phenylethyl)-2-(4''-methyl-1''-naphthalenesulfonylamino)butanamide
somatostatin receptor subtype-4
Therapeutics

Keywords

  • Adjuvant-induced inflammation
  • Anti-nociceptive effect
  • Formalin test
  • Somatostatin
  • Traumatic mononeuropathy

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Analgesic effects of the somatostatin sst4 receptor selective agonist J-2156 in acute and chronic pain models. / Sándor, K.; Elekes, K.; Szabó, Árpád; Pintér, E.; Engström, Mia; Wurster, Siegfried; Szolcsányi, J.; Helyes, Z.

In: European Journal of Pharmacology, Vol. 539, No. 1-2, 06.06.2006, p. 71-75.

Research output: Contribution to journalArticle

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AU - Engström, Mia

AU - Wurster, Siegfried

AU - Szolcsányi, J.

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