In the last two decades there has been an increasing interest in Europe in treating selectedpatients with early-stage breast cancer with accelerated partial breast irradiation(APBI) using external beam irradiation (EBI) (Magee et al. 1996; Ribeiro et al. 1993), interstitialbrachytherapy (BT) (Cionini et al. 1995; Clarke et al. 1994; Fentiman et al. 1991,1996, 2004; Johansson et al. 2002; Mayer and Nemeskeri 1993; Ott et al. 2004, 2005a,2005b; Polgar et al. 2000, 2002a, 2002b, 2004a, 2004b, 2005; Poti et al. 2004; Samuel et al.1999; Strnad et al. 2004), or intracavitary (MammoSite) BT (Niehoff et al. 2005). In thischapter, we give an overview of these European clinical trials of APBI including theirimplications for optimal patient selection, target definition, treatment technique, andquality assurance (QA). Finally, we discuss the development and status of the new Europeanmulticentric phase III APBI trial conducted by the Breast Cancer Working Groupof the Groupe Europeen de Curietherapie - European Society for Therapeutic Radiologyand Oncology (GEC-ESTRO). European experience with intraoperative radiotherapyfor APBI is discussed elsewhere (see Chapter 12).
|Title of host publication||Accelerated Partial Breast Irradiation|
|Subtitle of host publication||Techniques and Clinical ImplementationIrradiation|
|Publisher||Springer Berlin Heidelberg|
|Number of pages||19|
|ISBN (Print)||3540282025, 9783540282020|
|Publication status||Published - Dec 1 2006|
ASJC Scopus subject areas