An overview of european clinical trials of accelerated partial breast irradiation

Csaba Polgár, Tibor Major, Vratislav Strnad, Peter Niehoff, Oliver J. Ott, György Kovács

Research output: Chapter in Book/Report/Conference proceedingChapter


In the last two decades there has been an increasing interest in Europe in treating selectedpatients with early-stage breast cancer with accelerated partial breast irradiation(APBI) using external beam irradiation (EBI) (Magee et al. 1996; Ribeiro et al. 1993), interstitialbrachytherapy (BT) (Cionini et al. 1995; Clarke et al. 1994; Fentiman et al. 1991,1996, 2004; Johansson et al. 2002; Mayer and Nemeskeri 1993; Ott et al. 2004, 2005a,2005b; Polgar et al. 2000, 2002a, 2002b, 2004a, 2004b, 2005; Poti et al. 2004; Samuel et al.1999; Strnad et al. 2004), or intracavitary (MammoSite) BT (Niehoff et al. 2005). In thischapter, we give an overview of these European clinical trials of APBI including theirimplications for optimal patient selection, target definition, treatment technique, andquality assurance (QA). Finally, we discuss the development and status of the new Europeanmulticentric phase III APBI trial conducted by the Breast Cancer Working Groupof the Groupe Europeen de Curietherapie - European Society for Therapeutic Radiologyand Oncology (GEC-ESTRO). European experience with intraoperative radiotherapyfor APBI is discussed elsewhere (see Chapter 12).

Original languageEnglish
Title of host publicationAccelerated Partial Breast Irradiation
Subtitle of host publicationTechniques and Clinical ImplementationIrradiation
PublisherSpringer Berlin Heidelberg
Number of pages19
ISBN (Print)3540282025, 9783540282020
Publication statusPublished - Dec 1 2006


ASJC Scopus subject areas

  • Medicine(all)

Cite this

Polgár, C., Major, T., Strnad, V., Niehoff, P., Ott, O. J., & Kovács, G. (2006). An overview of european clinical trials of accelerated partial breast irradiation. In Accelerated Partial Breast Irradiation: Techniques and Clinical ImplementationIrradiation (pp. 227-245). Springer Berlin Heidelberg.