An organic chemist’s guide to electrospray mass spectrometric structure elucidation

Arnold Steckel, Gitta Schlosser

Research output: Contribution to journalReview article

1 Citation (Scopus)


Tandem mass spectrometry is an important tool for structure elucidation of natural and synthetic organic products. Fragmentation of odd electron ions (OE+) generated by electron ionization (EI) was extensively studied in the last few decades, however there are only a few systematic reviews available concerning the fragmentation of even-electron ions (EE+/EE) produced by the currently most common ionization techniques, electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI). This review summarizes the most important features of tandem mass spectra generated by collision-induced dissociation fragmentation and presents didactic examples for the unexperienced users.

Original languageEnglish
Article number611
Issue number3
Publication statusPublished - Feb 10 2019



  • CID
  • Collision-induced dissociation
  • ESI
  • MS/MS fragmentation
  • Structure elucidation
  • Tandem mass spectrometry

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this