An isobolographic analysis of the hypnotic effects of combinations of dexmedetomidine with fentanyl or diazepam in rats

G. Horváth, Margit Szikszay, György Rubicsek, G. Benedek

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The effects of the combinations of dexmedetomidine-fentanyl and dexmedetomidine-diazepam on the righting reflex were studied in rats. The doses that block the righting reflex for the agents given alone and for their combinations were determined with a probit procedure and compared with an isobolographic analysis. The interactions between dexmedetomidine and fentanyl or diazepam were found to be synergistic. In the dexmedetomidine-diazepam combination studies, less than one-fourth of the single drug dose (for each of two agents) was needed to produce the required effect. These data confirm synergistic interactions between dexmedetomidine and fentanyl or diazepam in producing hypnotic-anesthetic action.

Original languageEnglish
JournalLife Sciences
Volume50
Issue number23
DOIs
Publication statusPublished - 1992

Fingerprint

Dexmedetomidine
Fentanyl
Diazepam
Hypnotics and Sedatives
Rats
Righting Reflex
Anesthetics
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology

Cite this

An isobolographic analysis of the hypnotic effects of combinations of dexmedetomidine with fentanyl or diazepam in rats. / Horváth, G.; Szikszay, Margit; Rubicsek, György; Benedek, G.

In: Life Sciences, Vol. 50, No. 23, 1992.

Research output: Contribution to journalArticle

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AU - Benedek, G.

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