An investigation of the ability of Viscum album-activated granulocytes to regulate natural killer cells in vivo

T. Hajto, K. Hostanska

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The chemiluminescence (CL) responsiveness of polymorphonuclear leukocytes (PMN), natural killer (NK) activity and frequency of large granular lymphocytes (LGL) were investigated at various times in the peripheral blood of 16 breast cancer patients during treatment with iscador, a Viscum album preparation. The aim was to monitor its immunomodulatory effect. After a single infusion of iscador, PMN responses, NK activities and LGL frequencies increased significantly. The extent of the increase in these three parameters correlated in all patients, however there were considerable differences in kinetics. Six hours after iscador infusion, decreases in NK and LGL values were observed, which paralleled the enhancement of PMN responses; 24 hours later, after the decreases in PMN responses, significant increases in NK function and LGL level were observed. These data support the results of other investigators, that PMN may play an important role in the regulation of NK function. Nevertheless, CL assay of PMN has prognostic importance and together with LGL determination in blood may give a relatively easy, reliable and reproducible examination for monitoring various immunotherapeutic interventions.

Original languageEnglish
Pages (from-to)345-358
Number of pages14
JournalClinical Trials Journal
Volume23
Issue number6
Publication statusPublished - Dec 1 1986

Keywords

  • Natural killer cell
  • Viscum album
  • breast cancer
  • chemiluminescence assay
  • large granular lymphocyte

ASJC Scopus subject areas

  • Pharmacology (medical)

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