Szignifikáns inverz kapcsolat a pajzsmirigy-stimuláló hormon (TSH) és a prosztataspecifikus antigén (PSA) vérszintjei között 40–75 éves korú férfiakban

Translated title of the contribution: An inverse significant association between thyroid stimulatory hormone (TSH) and prostate specific antigen (PSA) blood levels in males 40–75 years of age

Tóth Zoltán, Gyarmati Béla, Szabó Tamás, B. Vásárhelyi

Research output: Contribution to journalArticle

Abstract

Introduction: Recent experiments and clinical studies indicate the contribution of thyroid hormones to prostate pathology. Aim: In our retrospective analyzis of university patient population, we evaluated the association between thyroid stimulatory hormone (TSH) and prostate specific antigen (PSA). Method: From the Laboratory Information System we retrieved the data of male patients between 40 and 75 years of age who had been subjected to simultaneous TSH and PSA measurements during the last 12 years (n = 7279). The association between logTSH and logPSA levels was tested with multiple regression analysis and adjusted for age. Results: Significant associations between logPSA and logTSH and age (r = 0.297 and 0.472, respectively) were detected. PSA levels were higher in patients with TSH below (n = 405) than in those with TSH within reference range (TSH 0,35–4,95 mU/ml) (n = 6698) (PSA level: 1.118 [0.639–2.338] vs. 0.920 [0.508–1.826] ng/ml, p<0.016). Based on estimates, a 10% decrease in TSH is associated with a 0.42% increase in PSA levels in our population. This corresponds to a 42% increase in PSA levels in the same patient if he would present with 0.2 mU/ml instead of 2.0 mU/ml TSH. Conclusion: The finding that hyperthyreosis might be associated with higher PSA levels indicates that PSA reference ranges would differ in hyperthyreotic and in euthyreotic patients. Probably the PSA clinical decision limits is also recommended to be modified according to the patient’s thyroid status.

Original languageHungarian
Pages (from-to)1376-1379
Number of pages4
JournalOrvosi hetilap
Volume160
Issue number35
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Prostate-Specific Antigen
Thyroid Hormones
Reference Values
Clinical Laboratory Information Systems
Population
Prostate
Thyroid Gland
Regression Analysis
Pathology

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Szignifikáns inverz kapcsolat a pajzsmirigy-stimuláló hormon (TSH) és a prosztataspecifikus antigén (PSA) vérszintjei között 40–75 éves korú férfiakban. / Zoltán, Tóth; Béla, Gyarmati; Tamás, Szabó; Vásárhelyi, B.

In: Orvosi hetilap, Vol. 160, No. 35, 01.01.2019, p. 1376-1379.

Research output: Contribution to journalArticle

@article{5916eeda985046ab8277224a62271a32,
title = "Szignifik{\'a}ns inverz kapcsolat a pajzsmirigy-stimul{\'a}l{\'o} hormon (TSH) {\'e}s a prosztataspecifikus antig{\'e}n (PSA) v{\'e}rszintjei k{\"o}z{\"o}tt 40–75 {\'e}ves kor{\'u} f{\'e}rfiakban",
abstract = "Introduction: Recent experiments and clinical studies indicate the contribution of thyroid hormones to prostate pathology. Aim: In our retrospective analyzis of university patient population, we evaluated the association between thyroid stimulatory hormone (TSH) and prostate specific antigen (PSA). Method: From the Laboratory Information System we retrieved the data of male patients between 40 and 75 years of age who had been subjected to simultaneous TSH and PSA measurements during the last 12 years (n = 7279). The association between logTSH and logPSA levels was tested with multiple regression analysis and adjusted for age. Results: Significant associations between logPSA and logTSH and age (r = 0.297 and 0.472, respectively) were detected. PSA levels were higher in patients with TSH below (n = 405) than in those with TSH within reference range (TSH 0,35–4,95 mU/ml) (n = 6698) (PSA level: 1.118 [0.639–2.338] vs. 0.920 [0.508–1.826] ng/ml, p<0.016). Based on estimates, a 10{\%} decrease in TSH is associated with a 0.42{\%} increase in PSA levels in our population. This corresponds to a 42{\%} increase in PSA levels in the same patient if he would present with 0.2 mU/ml instead of 2.0 mU/ml TSH. Conclusion: The finding that hyperthyreosis might be associated with higher PSA levels indicates that PSA reference ranges would differ in hyperthyreotic and in euthyreotic patients. Probably the PSA clinical decision limits is also recommended to be modified according to the patient’s thyroid status.",
keywords = "PSA levels, Reference range, Thyroid function, TSH levels",
author = "T{\'o}th Zolt{\'a}n and Gyarmati B{\'e}la and Szab{\'o} Tam{\'a}s and B. V{\'a}s{\'a}rhelyi",
year = "2019",
month = "1",
day = "1",
doi = "10.1556/650.2019.31340",
language = "Hungarian",
volume = "160",
pages = "1376--1379",
journal = "Orvosi Hetilap",
issn = "0030-6002",
publisher = "Akademiai Kiado",
number = "35",

}

TY - JOUR

T1 - Szignifikáns inverz kapcsolat a pajzsmirigy-stimuláló hormon (TSH) és a prosztataspecifikus antigén (PSA) vérszintjei között 40–75 éves korú férfiakban

AU - Zoltán, Tóth

AU - Béla, Gyarmati

AU - Tamás, Szabó

AU - Vásárhelyi, B.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Introduction: Recent experiments and clinical studies indicate the contribution of thyroid hormones to prostate pathology. Aim: In our retrospective analyzis of university patient population, we evaluated the association between thyroid stimulatory hormone (TSH) and prostate specific antigen (PSA). Method: From the Laboratory Information System we retrieved the data of male patients between 40 and 75 years of age who had been subjected to simultaneous TSH and PSA measurements during the last 12 years (n = 7279). The association between logTSH and logPSA levels was tested with multiple regression analysis and adjusted for age. Results: Significant associations between logPSA and logTSH and age (r = 0.297 and 0.472, respectively) were detected. PSA levels were higher in patients with TSH below (n = 405) than in those with TSH within reference range (TSH 0,35–4,95 mU/ml) (n = 6698) (PSA level: 1.118 [0.639–2.338] vs. 0.920 [0.508–1.826] ng/ml, p<0.016). Based on estimates, a 10% decrease in TSH is associated with a 0.42% increase in PSA levels in our population. This corresponds to a 42% increase in PSA levels in the same patient if he would present with 0.2 mU/ml instead of 2.0 mU/ml TSH. Conclusion: The finding that hyperthyreosis might be associated with higher PSA levels indicates that PSA reference ranges would differ in hyperthyreotic and in euthyreotic patients. Probably the PSA clinical decision limits is also recommended to be modified according to the patient’s thyroid status.

AB - Introduction: Recent experiments and clinical studies indicate the contribution of thyroid hormones to prostate pathology. Aim: In our retrospective analyzis of university patient population, we evaluated the association between thyroid stimulatory hormone (TSH) and prostate specific antigen (PSA). Method: From the Laboratory Information System we retrieved the data of male patients between 40 and 75 years of age who had been subjected to simultaneous TSH and PSA measurements during the last 12 years (n = 7279). The association between logTSH and logPSA levels was tested with multiple regression analysis and adjusted for age. Results: Significant associations between logPSA and logTSH and age (r = 0.297 and 0.472, respectively) were detected. PSA levels were higher in patients with TSH below (n = 405) than in those with TSH within reference range (TSH 0,35–4,95 mU/ml) (n = 6698) (PSA level: 1.118 [0.639–2.338] vs. 0.920 [0.508–1.826] ng/ml, p<0.016). Based on estimates, a 10% decrease in TSH is associated with a 0.42% increase in PSA levels in our population. This corresponds to a 42% increase in PSA levels in the same patient if he would present with 0.2 mU/ml instead of 2.0 mU/ml TSH. Conclusion: The finding that hyperthyreosis might be associated with higher PSA levels indicates that PSA reference ranges would differ in hyperthyreotic and in euthyreotic patients. Probably the PSA clinical decision limits is also recommended to be modified according to the patient’s thyroid status.

KW - PSA levels

KW - Reference range

KW - Thyroid function

KW - TSH levels

UR - http://www.scopus.com/inward/record.url?scp=85071419124&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85071419124&partnerID=8YFLogxK

U2 - 10.1556/650.2019.31340

DO - 10.1556/650.2019.31340

M3 - Article

C2 - 31448641

AN - SCOPUS:85071419124

VL - 160

SP - 1376

EP - 1379

JO - Orvosi Hetilap

JF - Orvosi Hetilap

SN - 0030-6002

IS - 35

ER -